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Abnova
A1CF Polyclonal Antibody, MaxPab™
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Product Details
H00029974-B01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A1CF (NP_620311.1, 1 a.a. approximately 594 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MEAVCLGTCP EPEASMSTAI PGLKKGNNAL QSIILQTLLE KENGQRKYGG PPPGWDAAPP ERGCEIFIGK LPRDLFEDEL IPLCEKIGKI YEMRMMMDFN GNNRGYAFVT FSNKVEAKNA IKQLNNYEIR NGRLLGVCAS VDNCRLFVGG IPKTKKREEI LSEMKKVTEG VVDVIVYPSA ADKTKNRGFA FVEYESHRAA AMARRKLLPG RIQLWGHGIA VDWAEPEVEV DEDTMSSVKI LYVRNLMLST SEEMIEKEFN NIKPGAVERV KKIRDYAFVH FSNREDAVEA MKALNGKVLD GSPIEVTLAK PVDKDSYVRY TRGTGGRGTM LQGEYTYSLG QVYDPTTTYL GAPVFYAPQT YAAIPSLHFP ATKGHLSNRA IIRAPSVRGA AGVRGLGGRG YLAYTGLGRG YQVKGDKRED KLYDILPGME LTPMNPVTLK PQGIKLAPQI LEEICQKNNW GQPVYQLHSA IGQDQRQLFL YKITIPALAS QNPAIHPFTP PKLSAFVDEA KTYAAEYTLQ TLGIPTDGGD GTMATAAAAA TAFPGYAVPN ATAPVSAAQL KQAVTLGQDL AAYTTYEVYP TFAVTARGDG YGTF
Target Information
Mammalian apolipoprotein B mRNA undergoes site-specific Cto U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and acomplementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNPR family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACF; Apo-B RNA editing protein; apo-B RNA editing protein; apobec-1 complementation factor (ACF) (ASP); APOBEC-1 stimulating protein; APOBEC1 complementation factor; APOBEC1-stimulating protein; MGC163391; RNA binding protein; RP11-564C4.2; unnamed protein product
Gene Aliases: A1CF; ACF; ACF64; ACF65; APOBEC1CF; ASP
UniProt ID: (Human) A1L4F2
Entrez Gene ID: (Human) 29974
mRNA processing
embryo implantation
mRNA localization resulting in posttranscriptional regulation of gene expression
cytidine to uridine editing
mRNA modification
low-density lipoprotein particle clearance
protein stabilization
chromosomal 5-methylcytosine DNA demethylation pathway
negative regulation of mRNA catabolic process
negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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