Sequence of this protein is as follows: APPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKVEAKNAIKQLNNYE
Mammalian apolipoprotein B mRNA undergoes site-specific Cto U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and acomplementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNPR family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: apo-B RNA editing protein; apobec-1 complementation factor; apobec-1 complementation factor (ACF) (ASP); Apobec-1 complementation factor APOBEC-1 stimulating protein; Apobec-1 complementation factor, APOBEC-1 stimulating protein; APOBEC-1 stimulating protein; APOBEC1 complementation factor; APOBEC1 complementation factort; APOBEC1-stimulating protein; MGC163391; RP11-564C4.2
Gene Aliases: 1810073H04Rik; A1CF; A1cft; ACF; ACF64; ACF65; Apobec-1; APOBEC1CF; ASP
Molecular Function: RNA metabolism protein