PA5-26631 has successfully been used to detect serotonin N-AT in both WB and IF applications.
AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.
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Protein Aliases: AA-NAT; Aralkylamine N-acetyltransferase; arylalkylamine N-acetyltransferase; DSPS; Serotonin acetylase; Serotonin N-acetyltransferase; SNAT
Gene Aliases: AANAT; DSPS; SNAT
UniProt ID: (Human) Q16613
Entrez Gene ID: (Human) 15