Immunogen sequence: FLTLCPELSLG WFEEGCLVAF IIGSLWDKER LMQESLTLHR SGGHIAHLHV LAVHRAFRQQ GRGPILLWR
Highest antigen sequence identity to the following orthologs - mouse 89%, rat 89%.
Arylalkylamine N-Acetyltransferase (AANAT) is the penultimate enzyme is melatonin synthesis. Hormonal melatonin has been implicated in sleep and circadian clock function. Large changes in the abundance of AANAT are believed to be responsible for the large day/night rhythms in melatonin synthesis in the pineal gland and retina (1,2). Most research shows that AANAT activity is regulated by controlling the steady-state levels of the protein. Recent research, however, suggests that another mechanism may also play a role in controlling melatonin production without altering AANAT protein and activity. This mechanism may explain the sudden physiological increase in circulating melatonin observed at the onset of the dark period in humans.
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Protein Aliases: AA-NAT; Aralkylamine N-acetyltransferase; arylalkylamine N-acetyltransferase; Serotonin acetylase; Serotonin N-acetyltransferase; SNAT
Gene Aliases: AANAT; DSPS; SNAT
UniProt ID: (Human) Q16613
Entrez Gene ID: (Human) 15