This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: RLSTVRAADT IIGFEHGTAV ERGTHEELLE RKGVYFTLVT LQSQGNQALN EEDIKDATED DMLARTFSRG SYQDSLRASI RQRSKSQLSY LVHEPPLAVV DHKSTYEEDR KDKDIPVQEE VEPAPVRRIL K
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 79%.
ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
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Protein Aliases: ABC member 16; ABC member 16, MDR/TAP subfamily; ABC16; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; Bile salt export pump; BRIC2; BSEP; MDR/TAP subfamily; PFIC-2; PFIC2; PGY4; progressive familial intrahepatic cholestasis 2; sister p-glycoprotein; SPGP
Gene Aliases: ABC16; ABCB11; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP
UniProt ID: (Human) O95342
Entrez Gene ID: (Human) 8647