Proteintech

ABCB6 Polyclonal Antibody

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ABCB6 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of MCF-7 cells using 51007-1-AP (ABCB6 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

ABCB6 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer using 51007-1-AP (ABCB6 antibody) at dilution of 1:50 (under 10x lens).

ABCB6 Antibody in Western Blot (WB) — Raji cells were subjected to SDS PAGE followed by western blot with 51007-1-AP (ABCB6 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Product Details

51007-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 2 publications 2 publications
Immunohistochemistry (IHC)	-	View 1 publication 1 publication
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunocytochemistry (ICC/IF)	1:20-1:200	-

Product Specifications
Species Reactivity	Human
Published species	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	ABCB6 Fusion Protein Ag0461 (57-267 aa encoded by BC000559) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.2 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: AGADSLSWG AGPRISPYVL QLLLATLQAA LPLAGLAGRV GTARGAPLPS YLLLASVLES LAGACGLWLL VVERSQARQR LAMGIWIKFR HSPGLLLLWT VAFAAENLAL VSWNSPQWWW ARADLGQQVQ FSLWVLRYVV SGGLFVLGLW APGLRPQSYT LQVHEEDQDV ERSQVRSAAQ QSTWRDFGRK LRLLSGYLWP RGSPALQLVV LI (57-267 aa encoded by BC000559)

Target Information

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies. This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Hepatitis C virus core protein triggers abnormal porphyrin metabolism in human hepatocellular carcinoma cells.

PloS one

Nakano T,Moriya K,Koike K,Horie T

Fri Jan 11 00:00:00 EST 2019

Mutations in ABCB6 cause dyschromatosis universalis hereditaria.

The Journal of investigative dermatology

Zhang C,Li D,Zhang J,Chen X,Huang M,Archacki S,Tian Y,Ren W,Mei A,Zhang Q,Fang M,Su Z,Yin Y,Liu D,Chen Y,Cui X,Li C,Yang H,Wang Q,Wang J,Liu M,Deng Y

Sun Sep 01 00:00:00 EDT 2013

Mutations in ABCB6 cause dyschromatosis universalis hereditaria.

The Journal of investigative dermatology

Zhang C,Li D,Zhang J,Chen X,Huang M,Archacki S,Tian Y,Ren W,Mei A,Zhang Q,Fang M,Su Z,Yin Y,Liu D,Chen Y,Cui X,Li C,Yang H,Wang Q,Wang J,Liu M,Deng Y

Sun Sep 01 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: ATP-binding cassette half-transporter; ATP-binding cassette sub-family B member 6, mitochondrial; ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group); EST45597; FLJ22414; Mitochondrial ABC transporter 3; Mt-ABC transporter 3; P-glycoprotein-related protein; Ubiquitously-expressed mammalian ABC half transporter

Gene Aliases: ABC; ABC14; ABCB6; DUH3; LAN; MCOPCB7; MTABC3; PRP; PSHK2; UMAT

UniProt ID: (Human) Q9NP58

Entrez Gene ID: (Human) 10058

Molecular Function: ATP-binding cassette (ABC) transporter