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Proteintech
ABCD4 Polyclonal Antibody
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Product Details
15935-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ABCD4 fusion protein Ag8783
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SDVAGYTHRI GQLRETLLDM SLKSQDCEIL GESKWGLDTP PGWPAAEPAD TAFLLERVSI SAPSSDKPLI KDLSLKISEG QSLLITGNTG TGKTSLLRVL GGLWTSTRGS VQMLTDFGPH GVLFLPQKPF FTDGTLREQV IYPLKEVYPD SGSADDERIL RFLELAGLSN LVARTEGLDQ QVDWNWYDVL SPGEMQRLSF ARLFYLQPKY AVLDEATSAL TEEVESELYR IGQQLGMTFI SVGHRQSLEK FHSLVLKLCG GGRWELMRIK VE
Target Information
The peroxisomal membrane contains several ATP-binding cassette (ABC) transporters, ABCD1-4 that are known to be present in the human peroxisome membrane. All four proteins are ABC half-transporters, which dimerize to form an active transporter. A mutation in the ABCD1 gene causes X-linked adreno-leukodystrophy (X-ALD), a peroxisomal disorder which affects lipid storage. ABCD2 in mouse is expressed at high levels in the brain and adrenal organs, which are adversely affected in X-ALD. The peroxisomal membrane comprises two quantitatively major proteins, PMP22 and ABCD3. ABCD3 is associated with irregularly shaped vesicles which may be defective peroxisomes or peroxisome precursors. ABCD1 localizes to peroxisomes. ABCB7 is a half-transporter involved in the transport of heme from the mitochondria to the cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 69 kDa peroxisomal ABC-transporter; ATP-binding cassette sub-family D member 4; ATP-binding cassette, sub-family D (ALD), member 4; Lysosomal cobalamin transporter ABCD4; P70R; Peroxisomal membrane protein 1-like; Peroxisomal membrane protein 69; peroxisomal membrane protein, 70 kDa-related; PMP69; PMP70-related protein; PXMP1-L
Gene Aliases: ABC41; ABCD4; EST352188; MAHCJ; P69r; P70R; P79R; PMP69; PXMP1L
UniProt ID: (Human) O14678, (Mouse) O89016
Entrez Gene ID: (Human) 5826, (Mouse) 19300
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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