|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 359 and 606 of Human ABCD4|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30140 targets ABCD4 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30140 immunogen is recombinant fragment corresponding to a region within amino acids 359 and 606 of Human ABCD4.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in at least two different transcript variants, one which is protein-coding and one which is probably not protein-coding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 69 kDa peroxisomal ABC-transporter; ABC41; ATP-binding cassette sub-family D member 4; ATP-binding cassette, sub-family D (ALD), member 4; EST352188; P70R; P79R; Peroxisomal membrane protein 1-like; Peroxisomal membrane protein 69; PMP69; PMP70-related protein; PXMP1-L; PXMP1L
Gene Aliases: ABC41; ABCD4; EST352188; MAHCJ; P70R; P79R; PMP69; PXMP1L
UniProt ID: (Human) O14678
Entrez Gene ID: (Human) 5826
Molecular Function: transporter
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