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ABL2 Polyclonal Antibody

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ABL2 Polyclonal Antibody

Product Details

BS-1230R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human ABL2, amino acids 935-1050.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

ABL2 (Arg) is an Abl-related non-receptor protein tyrosine kinase that links cell surface receptors to cell proliferation and/or cytoskeletal reorganization. Abl2 encodes a member of the Abelson family of nonreceptor tyrosine protein kinase. The protein is highly similar to the ABL1 protein, including the tyrosine kinase, SH2 and SH3 domains, and has a role in cytoskeletal rearrangements by its C-terminal F-actin- and microtubule-binding sequences. Abl2 is expressed in both normal and tumor cells, and is involved in translocation with the ETV6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Abelson murine leukemia viral (v-abl) oncogene homolog 2; Abelson murine leukemia viral oncogene homolog 2; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; Abl1-related gene product; abl2; arg tyrosine kinase; c-abl oncogene 2, non-receptor tyrosine kinase; FLJ22224; FLJ31718; FLJ41441; tyrosine kinase ARG; Tyrosine-protein kinase ABL2; Tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene 2; v-abl Abelson murine leukemia viral oncogene homolog 2; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

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Gene Aliases: AA536808; ABL2; ABLL; ARG

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UniProt ID: (Human) P42684

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Entrez Gene ID: (Human) 27, (Mouse) 11352, (Rat) 304883

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Function(s)
nucleotide binding magnesium ion binding phosphotyrosine binding actin monomer binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding enzyme activator activity kinase activity transferase activity enzyme binding manganese ion binding metal ion binding actin filament binding receptor binding transferase activity, transferring phosphorus-containing groups molecular_function
Process(es)
cell adhesion signal transduction epidermal growth factor receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration regulation of autophagy positive regulation of neuron projection development peptidyl-tyrosine phosphorylation regulation of endocytosis regulation of cell adhesion regulation of actin cytoskeleton organization cellular response to oxidative stress negative regulation of Rho protein signal transduction exploration behavior protein modification process cellular response to retinoic acid positive regulation of establishment of T cell polarity regulation of cell motility positive regulation of T cell migration protein phosphorylation phagocytosis substrate-dependent cell migration, cell extension actin filament organization learning visual learning positive regulation of phospholipase C activity phosphorylation neuron remodeling cell migration cerebellum morphogenesis negative regulation of cell-cell adhesion actin cytoskeleton organization positive regulation of protein binding cellular protein localization peptidyl-tyrosine autophosphorylation regulation of cell proliferation positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response alpha-beta T cell differentiation platelet-derived growth factor receptor signaling pathway dendrite morphogenesis neuromuscular process controlling balance actin filament bundle assembly positive regulation of oxidoreductase activity Bergmann glial cell differentiation positive regulation of ERK1 and ERK2 cascade dendritic spine maintenance positive regulation of interleukin-2 secretion positive regulation of interferon-gamma secretion regulation of extracellular matrix organization positive regulation of Wnt signaling pathway, planar cell polarity pathway negative regulation of endothelial cell apoptotic process biological_process cell differentiation regulation of apoptotic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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