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Proteintech
ACAP1 Polyclonal Antibody
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Product Details
20135-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ACAP1 Fusion Protein Ag14068 (20-251 aa encoded by BC018543)
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Amount
27 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SIELVEAEV SELETRLEKL LKLGTGLLES GRHYLAASRA FVVGICDLAR LGPPEPMMAE CLEKFTVSLN HKLDSHAELL DATQHTLQQQ IQTLVKEGLR GFREARRDFW RGAESLEAAL THNAEVPRRR AQEAEEAGAA LRTARAGYRG RALDYALQIN VIEDKRKFDI MEFVLRLVEA QATHFQQGHE ELSRLSQYRK ELGAQLHQLV LNSAREKRDM EQRHVLLKQK ELG (20-251 aa encoded by BC018543)
Target Information
ACAP1, also known as Centaurin-beta-1 (CENTB1), is a 740 amino acid containing transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain and a PH domain that binds to phospholipids. ACAP1, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6), is required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. It mediates CENTB1-binding to phosphatidylinositol 3,5-bisphosphate (PIP2) or phosphatidylinositol 3,4,5-trisphosphate (PIP3) containing membranes. Along with ACAP2, ACAP1 is recruited to platelet-derived growth factor (PDGF) induced dorsal membrane ruffles in NIH 3T3 mouse fibroblasts, while over expression inhibited ruffle formation. It is widely expressed in most tissues with high expression in lung and spleen and low expression in heart, kidney, liver and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Arf GAP with coiled coil, ANK repeat and PH domains 1; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; centaurin beta 1; centaurin, beta 1; Centaurin-beta-1; Cnt-b1; KIAA0050
Gene Aliases: ACAP1; CENTB1; KIAA0050
UniProt ID: (Human) Q15027, (Mouse) Q8K2H4
Entrez Gene ID: (Human) 9744, (Mouse) 216859, (Rat) 287443
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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