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Agrisera
ACD1/Accelerated cell death 1 Polyclonal Antibody
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FIGURE: 1 / 2
ACD1/Accelerated cell death 1 Antibody (AS11-1783) in WB
Arabidopsis thaliana wild ecotype Columbia was grown for four weeks under continuous illumination and then transferred to complete darkness for five days. Several leaves were harvested from the plants before they were transferred to darkness (0 d) or after they were kept for five days (5 d). Protein was extracted with the SDS extraction solution containing 50 m M Tris (p H 6.8), 10% (w/v) glycerol, 2% (w/v)... View More
Product Details
AS11-1783
Product Specifications
Species Reactivity
Plant
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant PaO from Arabidopsis thaliana.
Conjugate
Form
Lyophilized
Storage buffer
whole serum
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
Target Information
ACD1 encodes a chloroplast-associated enzyme of the chlorophyll catabolic pathway that localizes to plastids (consistent with a chloroplast transit peptide) and functions during leaf senescence and stress-related chlorophyll breakdown. The ACD1 protein is a Rieske-type oxygenase/monooxygenase of the pheophorbide a oxygenase (PaO) step, containing a Rieske 2Fe-2S cluster-binding module and a non-heme iron catalytic center typical of aromatic-ring-hydroxylating dioxygenase-like enzymes, enabling oxygenolytic opening of the pheophorbide a tetrapyrrole macrocycle. Biologically, ACD1 activity is required to convert pheophorbide a into downstream chlorophyll catabolites; when ACD1/PaO activity is reduced (e.g., by antisense suppression), pheophorbide a accumulates and triggers cellular damage and accelerated cell death, including photooxidative injury upon re-illumination after dark-induced senescence, demonstrating that controlled PaO function is essential both for efficient chlorophyll detoxification during senescence and for limiting pro-death signaling/toxicity from chlorophyll catabolic intermediates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACCELERATED CELL DEATH 1; AT3G44880; LETHAL LEAF-SPOT 1 HOMOLOG; LLS1; PAO; PHEOPHORBIDE A OXYGENASE
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