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Proteintech
ACE Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
24743-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ACE Fusion Protein Ag20654 (390-739 aa encoded by BC036375)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.36 mg/mL
Amount
54 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: FYNGKDFRI KQCTTVNLED LVVAHHEMGH IQYFMQYKDL PVALREGANP GFHEAIGDVL ALSVSTPKHL HSLNLLSSEG GSDEHDINFL MKMALDKIAF IPFSYLVDQW RWRVFDGSIT KENYNQEWWS LRLKYQGLCP PVPRTQGDFD PGAKFHIPSS VPYIRYFVSF IIQFQFHEAL CQAAGHTGPL HKCDIYQSKE AGQRLATAMK LGFSRPWPEA MQLITGQPNM SASAMLSYFK PLLDWLRTEN ELHGEKLGWP QYNWTPNSDD FYNETETKIF LQFYDQTGIW DHGAPHLLPP SQARGTREAP VYMSKRAASS GPPGSPKLPP AAQGHGEVPV HDLLWHPGPP V (390-739 aa encoded by BC036375)
Target Information
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes-the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: angiotensin 1 converting enzyme 1; angiotensin converting enzyme precursor (EC 3.4.15.1); angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; angiotensin I-converting enzyme; angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1); angiotensin I-converting enzyme precursor (EC 3.4.15.1); angiotensin-converting enzyme; angiotensin-converting enzyme-like; carboxycathepsin; CD143 antigen; dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); dipeptidyl carboxypeptidase I; dipeptidyl peptidase; kininase II; MGC26566; peptidase P; unnamed protein product; Zn2+ carboxydipeptidase enzyme which transforms angiotensin I into angiotensin II an active vasoconstrictor protein; splice-site mutation IVS25+1G-->A leads to the retention of intron 25 resulting in a frameshift which leads to a premature stop codon
Gene Aliases: ACE1; CD143; DCP; DCP1; StsRR92
UniProt ID: (Human) P12821, (Mouse) P09470, (Rat) P47820
Entrez Gene ID: (Human) 1636, (Mouse) 11421, (Rat) 24310
actin binding
endopeptidase activity
metallocarboxypeptidase activity
metalloendopeptidase activity
protein binding
peptidase activity
metallopeptidase activity
exopeptidase activity
tripeptidyl-peptidase activity
peptidyl-dipeptidase activity
zinc ion binding
chloride ion binding
mitogen-activated protein kinase kinase binding
bradykinin receptor binding
mitogen-activated protein kinase binding
metallodipeptidase activity
heterocyclic compound binding
kidney development
angiotensin maturation
regulation of blood vessel size by renin-angiotensin
neutrophil mediated immunity
regulation of systemic arterial blood pressure by renin-angiotensin
positive regulation of systemic arterial blood pressure
proteolysis
peptide metabolic process
spermatogenesis
regulation of blood pressure
male gonad development
embryo development ending in birth or egg hatching
posttranscriptional regulation of gene expression
negative regulation of gene expression
substance P catabolic process
bradykinin catabolic process
regulation of smooth muscle cell migration
organ regeneration
response to lipopolysaccharide
angiotensin-activated signaling pathway
vasoconstriction
vasodilation
hormone metabolic process
hormone catabolic process
eating behavior
positive regulation of apoptotic process
peptide catabolic process
positive regulation of blood pressure
positive regulation of vasoconstriction
negative regulation of glucose import
regulation of synaptic plasticity
lung alveolus development
beta-amyloid metabolic process
arachidonic acid secretion
positive regulation of neurogenesis
heart contraction
regulation of angiotensin metabolic process
angiogenesis involved in coronary vascular morphogenesis
cell proliferation in bone marrow
regulation of heart rate by cardiac conduction
negative regulation of calcium ion import
regulation of hematopoietic stem cell proliferation
regulation of blood circulation
negative regulation of gap junction assembly
response to hypoxia
female pregnancy
response to xenobiotic stimulus
lung development
response to nutrient levels
response to laminar fluid shear stress
cellular response to glucose stimulus
response to dexamethasone
response to thyroid hormone
cellular response to aldosterone
blood vessel remodeling
regulation of renal output by angiotensin
antigen processing and presentation of peptide antigen via MHC class I
regulation of vasoconstriction
mononuclear cell proliferation
hematopoietic stem cell differentiation
regulation of blood vessel diameter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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