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Invitrogen
ACE Polyclonal Antibody
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FIGURE: 1 / 3
ACE Antibody (PA5-47964) in IHC (P)
Immunohistochemical analysis of ACE in immersion fixed paraffin-embedded sections of human kidney array. Samples were incubated in ACE polyclonal antibody (Product # PA5-47964) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies ... View More
Product Details
PA5-47964
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human ACE/CD143 Leu30-Leu1261
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, less than 10% cross-reactivity with recombinant mouse ACE is observed and less than 5% cross-reactivity with recombinant human ACE-2 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes-the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACE; angiotensin converting enzyme precursor (EC 3.4.15.1); angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I-converting enzyme; angiotensin I-converting enzyme precursor (EC 3.4.15.1); Angiotensin-converting enzyme; carboxycathepsin; CD143; CD143 antigen; dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase I; Kininase II; MGC26566; peptidase P; unnamed protein product; Zn2+ carboxydipeptidase enzyme which transforms angiotensin I into angiotensin II an active vasoconstrictor protein; splice-site mutation IVS25+1G-->A leads to the retention of intron 25 resulting in a frameshift which leads to a premature stop codon
Gene Aliases: ACE; ACE1; CD143; DCP; DCP1
UniProt ID: (Human) P12821
Entrez Gene ID: (Human) 1636
actin binding
endopeptidase activity
carboxypeptidase activity
metallocarboxypeptidase activity
metalloendopeptidase activity
protein binding
calmodulin binding
peptidase activity
metallopeptidase activity
exopeptidase activity
tripeptidyl-peptidase activity
peptidyl-dipeptidase activity
zinc ion binding
hydrolase activity
chloride ion binding
mitogen-activated protein kinase kinase binding
bradykinin receptor binding
metal ion binding
mitogen-activated protein kinase binding
metallodipeptidase activity
kidney development
blood vessel remodeling
angiotensin maturation
regulation of renal output by angiotensin
regulation of blood vessel size by renin-angiotensin
neutrophil mediated immunity
antigen processing and presentation of peptide antigen via MHC class I
regulation of systemic arterial blood pressure by renin-angiotensin
positive regulation of systemic arterial blood pressure
proteolysis
spermatogenesis
regulation of blood pressure
male gonad development
posttranscriptional regulation of gene expression
negative regulation of gene expression
substance P catabolic process
bradykinin catabolic process
regulation of smooth muscle cell migration
regulation of vasoconstriction
mononuclear cell proliferation
angiotensin-activated signaling pathway
vasodilation
hormone metabolic process
hormone catabolic process
peptide catabolic process
regulation of synaptic plasticity
beta-amyloid metabolic process
arachidonic acid secretion
heart contraction
regulation of angiotensin metabolic process
hematopoietic stem cell differentiation
cell proliferation in bone marrow
regulation of heart rate by cardiac conduction
regulation of blood vessel diameter
regulation of hematopoietic stem cell proliferation
negative regulation of gap junction assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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