In direct ELISAs, less than 10% cross-reactivity with recombinant mouse ACE is observed and less than 5% cross-reactivity with recombinant human ACE-2 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.
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Protein Aliases: ACE; ACE1; angiotensin converting enzyme, somatic isoform; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript; Angiotensin-converting enzyme; Angiotensin-converting enzyme, soluble form; carboxycathepsin; CD143; CD143 antigen; DCP; DCP1; dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase I; Kininase II; MGC26566; MVCD3; peptidase P; testicular ECA
Gene Aliases: ACE; ACE1; CD143; DCP; DCP1; ICH; MVCD3
UniProt ID: (Human) P12821
Entrez Gene ID: (Human) 1636