Invitrogen

ACE Polyclonal Antibody

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ACE Polyclonal Antibody

Product Details

PA5-86568

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide, corresponding to amino acids 920-950 of Human ACE.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2803338

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes-the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ACE; angiotensin 1 converting enzyme 1; angiotensin converting enzyme, somatic isoform; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript; angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1); Angiotensin-converting enzyme; carboxycathepsin; CD143; CD143 antigen; dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); Dipeptidyl carboxypeptidase I; dipeptidyl peptidase; Kininase II; MGC26566; peptidase P; testicular ECA

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Gene Aliases: ACE; ACE1; AW208573; CD143; DCP; DCP1; ICH; MVCD3; StsRR92

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UniProt ID: (Human) P12821, (Mouse) P09470, (Rat) P47820

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Entrez Gene ID: (Human) 1636, (Mouse) 11421, (Rat) 24310

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Function(s)
endopeptidase activity carboxypeptidase activity drug binding metallopeptidase activity exopeptidase activity tripeptidyl-peptidase activity peptidyl-dipeptidase activity zinc ion binding chloride ion binding mitogen-activated protein kinase kinase binding bradykinin receptor binding mitogen-activated protein kinase binding metallodipeptidase activity actin binding protein binding peptidase activity lytic transglycosylase activity mannosidase activity mannosyl-oligosaccharide mannosidase activity galactosidase activity glucosidase activity trehalase activity fucosidase activity hexosaminidase activity amylase activity hydrolase activity dextrin alpha-glucosidase activity starch alpha-glucosidase activity metal ion binding beta-glucanase activity beta-6-sulfate-N-acetylglucosaminidase activity glucan endo-1,4-beta-glucosidase activity metalloprotease protease protein modifying enzyme
Process(es)
kidney development blood vessel remodeling angiotensin maturation angiotensin catabolic process in blood regulation of renal output by angiotensin neutrophil mediated immunity antigen processing and presentation of peptide antigen via MHC class I regulation of systemic arterial blood pressure by renin-angiotensin spermatogenesis regulation of blood pressure regulation of smooth muscle cell migration regulation of vasoconstriction mononuclear cell proliferation regulation of vasodilation hormone catabolic process peptide catabolic process beta-amyloid metabolic process arachidonic acid secretion heart contraction regulation of angiotensin metabolic process hematopoietic stem cell differentiation positive regulation of protein tyrosine kinase activity cell proliferation in bone marrow positive regulation of peptidyl-tyrosine autophosphorylation regulation of hematopoietic stem cell proliferation negative regulation of gap junction assembly positive regulation of peptidyl-cysteine S-nitrosylation positive regulation of systemic arterial blood pressure proteolysis peptide metabolic process posttranscriptional regulation of gene expression negative regulation of gene expression bradykinin catabolic process sensory perception of pain organ regeneration negative regulation of protein binding positive regulation of protein binding response to lipopolysaccharide vasoconstriction eating behavior positive regulation of apoptotic process lung alveolus development positive regulation of inflammatory response positive regulation of neurogenesis angiogenesis involved in coronary vascular morphogenesis negative regulation of calcium ion import response to hypoxia brain development female pregnancy aging male gonad development lung development response to nutrient levels response to laminar fluid shear stress response to drug cellular response to glucose stimulus response to dexamethasone response to thyroid hormone
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