Search

  • 주문 현황
  • 빠른주문

Invitrogen

ACE Polyclonal Antibody

View all (35) ACE antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
ACE Polyclonal Antibody

Product Details

PA5-95149

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Angiotensin Converting Enzyme 1 (130-144aa ANLPLAKRQQYNALL).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide, 0.05mg thimerosal

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2806954

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: A549 whole cell, HELA whole cell, 22RV1 whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes-the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: ACE; angiotensin converting enzyme precursor (EC 3.4.15.1); angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I-converting enzyme; angiotensin I-converting enzyme precursor (EC 3.4.15.1); Angiotensin-converting enzyme; carboxycathepsin; CD143; CD143 antigen; dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase I; dipeptidyl peptidase; Kininase II; MGC26566; peptidase P; unnamed protein product; Zn2+ carboxydipeptidase enzyme which transforms angiotensin I into angiotensin II an active vasoconstrictor protein; splice-site mutation IVS25+1G-->A leads to the retention of intron 25 resulting in a frameshift which leads to a premature stop codon

View more View less

Gene Aliases: ACE; ACE1; AW208573; CD143; DCP; DCP1

View more View less

UniProt ID: (Human) P12821, (Mouse) P09470

View more View less

Entrez Gene ID: (Human) 1636, (Mouse) 11421

View more View less

Function(s)
actin binding endopeptidase activity carboxypeptidase activity metallocarboxypeptidase activity metalloendopeptidase activity protein binding calmodulin binding peptidase activity metallopeptidase activity exopeptidase activity tripeptidyl-peptidase activity peptidyl-dipeptidase activity zinc ion binding hydrolase activity chloride ion binding mitogen-activated protein kinase kinase binding bradykinin receptor binding metal ion binding mitogen-activated protein kinase binding metallodipeptidase activity drug binding lytic transglycosylase activity mannosidase activity mannosyl-oligosaccharide mannosidase activity galactosidase activity glucosidase activity trehalase activity fucosidase activity hexosaminidase activity amylase activity dextrin alpha-glucosidase activity starch alpha-glucosidase activity beta-glucanase activity beta-6-sulfate-N-acetylglucosaminidase activity glucan endo-1,4-beta-glucosidase activity metalloprotease protease protein modifying enzyme
Process(es)
kidney development blood vessel remodeling angiotensin maturation regulation of renal output by angiotensin regulation of blood vessel size by renin-angiotensin neutrophil mediated immunity antigen processing and presentation of peptide antigen via MHC class I regulation of systemic arterial blood pressure by renin-angiotensin positive regulation of systemic arterial blood pressure proteolysis spermatogenesis regulation of blood pressure male gonad development posttranscriptional regulation of gene expression negative regulation of gene expression substance P catabolic process bradykinin catabolic process regulation of smooth muscle cell migration regulation of vasoconstriction mononuclear cell proliferation angiotensin-activated signaling pathway vasodilation hormone metabolic process hormone catabolic process peptide catabolic process regulation of synaptic plasticity beta-amyloid metabolic process arachidonic acid secretion heart contraction regulation of angiotensin metabolic process hematopoietic stem cell differentiation cell proliferation in bone marrow regulation of heart rate by cardiac conduction regulation of blood vessel diameter regulation of hematopoietic stem cell proliferation negative regulation of gap junction assembly peptide metabolic process sensory perception of pain organ regeneration negative regulation of protein binding positive regulation of protein binding response to lipopolysaccharide vasoconstriction eating behavior positive regulation of apoptotic process lung alveolus development positive regulation of inflammatory response positive regulation of neurogenesis angiogenesis involved in coronary vascular morphogenesis positive regulation of protein tyrosine kinase activity negative regulation of calcium ion import positive regulation of peptidyl-tyrosine autophosphorylation positive regulation of peptidyl-cysteine S-nitrosylation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support