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Proteintech
ACKR2 Polyclonal Antibody
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Product Details
11386-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ACKR2 Fusion Protein Ag1941 (74-384 aa encoded by BC008816)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YVPRRRMVE IYLLNLAISN LLFLVTLPFW GISVAWHWVF GSFLCKMVST LYTINFYSGI FFISCMSLDK YLEIVHAQPY HRLRTRAKSL LLATIVWAVS LAVSIPDMVF VQTHENPKGV WNCHADFGGH GTIWKLFLRF QQNLLGFLLP LLAMIFFYSR IGCVLVRLRP AGQGRALKIA AALVVAFFVL WFPYNLTLFL HTLLDLQVFG NCEVSQHLDY ALQVTESIAF LHCCFSPILY AFSSHRFRQY LKAFLAAVLG WHLAPGTAQA SLSSCSESSI LTAQEEMTGM NDLGERQSEN YPNKEDVGNK SA (74-384 aa encoded by BC008816)
Target Information
This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Atypical chemokine receptor 2; C-C chemokine receptor D6; CC-chemokine-binding receptor JAB61; CCR10-related receptor; chemokine (C-C motif) receptor 9; chemokine (C-C) receptor 9; chemokine binding protein 2; chemokine decoy receptor D6; Chemokine receptor CCR-10; Chemokine receptor CCR-9; chemokine receptor D6; Chemokine-binding protein 2; Chemokine-binding protein D6; D6 beta-chemokine receptor; unnamed protein product
Gene Aliases: ACKR2; AI464239; CCBP2; CCR10; CCR9; CMKBR9; D6; hD6
UniProt ID: (Human) O00590, (Mouse) O08707
Entrez Gene ID: (Human) 1238, (Mouse) 59289, (Rat) 140473
receptor-mediated endocytosis
chemotaxis
inflammatory response
signal transduction
G-protein coupled receptor signaling pathway
neutrophil activation
chemokine-mediated signaling pathway
immune response
positive regulation of cytosolic calcium ion concentration
calcium-mediated signaling
intracellular signal transduction
cell chemotaxis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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