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ACOX1 Polyclonal Antibody

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ACOX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human liver cancer using 10957-1-AP (ACOX1 antibody) at dilution of 1:100 (under 40x lens).

ACOX1 Antibody in Western Blot (WB) — Mouse kidney tissue were subjected to SDS PAGE followed by western blot with 10957-1-AP (ACOX1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

Product Details

10957-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 17 publications 17 publications
Immunohistochemistry (IHC)	-	View 2 publications 2 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunocytochemistry (ICC/IF)	-	View 2 publications 2 publications
Miscellaneous PubMed (Misc)	-	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	ACOX1 Fusion Protein Ag1405 (275-660 aa encoded by BC010425) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.3 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: YGTMVFVRS FLVGEAARAL SKACTIAIRY SAVRHQSEMK PGEPEPQILD FQTQQYKLFP LLATAYAFQF VGAYMKETYH RINEGIGQGD LSELPELHAL TAGLKAFTSW TANTGIEACR MACGGHGYSH CSGLPNIYVN FTPSCTFEGE NTVMMLQTAR FLMKSYDQVH SGKLVCGMVS YLNDLPSQRI QPQQVAVWPT MVDINSPESL TEAYKLRAAR LVEIAAKNLQ KEVIHRKSKE VAWNLTSVDL VRASEAHCHY VVVKLFSEKL LKIQDKAIQA VLRSLCLLYS LYGISQNAGD FLQGSIMTEP QITQVNQRVK ELLTLIRSDA VALVDAFDFQ DVTLGSVLGR YDGNVYENLF EWAKNSPLNK AEVHESYKHL KSLQSKL (275-660 aa encoded by BC010425 )

Target Information

The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA-540 expression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Kumar S,Rani R,Karns R,Gandhi CR

Fri Mar 01 00:00:00 EST 2019

Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA-540 expression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Kumar S,Rani R,Karns R,Gandhi CR

Fri Mar 01 00:00:00 EST 2019

Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission.

The Journal of clinical investigation

Park H,He A,Tan M,Johnson JM,Dean JM,Pietka TA,Chen Y,Zhang X,Hsu FF,Razani B,Funai K,Lodhi IJ

Fri Feb 01 00:00:00 EST 2019

MiR-31-5p-ACOX1 Axis Enhances Tumorigenic Fitness in Oral Squamous Cell Carcinoma Via the Promigratory Prostaglandin E2.

Theranostics

Lai YH,Liu H,Chiang WF,Chen TW,Chu LJ,Yu JS,Chen SJ,Chen HC,Tan BC

Tue Dec 11 00:00:00 EST 2018

PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.

EBioMedicine

Lyu Z,Mao Z,Li Q,Xia Y,Liu Y,He Q,Wang Y,Zhao H,Lu Z,Zhou Q

Sat Dec 01 00:00:00 EST 2018

SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.

EMBO reports

Chen XF,Tian MX,Sun RQ,Zhang ML,Zhou LS,Jin L,Chen LL,Zhou WJ,Duan KL,Chen YJ,Gao C,Cheng ZL,Wang F,Zhang JY,Sun YP,Yu HX,Zhao YZ,Yang Y,Liu WR,Shi YH,Xiong Y,Guan KL,Ye D

Tue May 01 00:00:00 EDT 2018

A novel case of ACOX2 deficiency leads to recognition of a third human peroxisomal acyl-CoA oxidase.

Biochimica et biophysica acta. Molecular basis of disease

Ferdinandusse S,Denis S,van Roermund CWT,Preece MA,Koster J,Ebberink MS,Waterham HR,Wanders RJA

Thu Mar 01 00:00:00 EST 2018

Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury.

Scientific reports

Zhang W,Zhong W,Sun Q,Sun X,Zhou Z

Thu Jan 11 00:00:00 EST 2018

p38α MAPK antagonizing JNK to control the hepatic fat accumulation in pediatric patients onset intestinal failure.

Cell death & disease

Xiao Y,Wang J,Yan W,Zhou K,Cao Y,Cai W

Thu Oct 12 00:00:00 EDT 2017

p38α MAPK antagonizing JNK to control the hepatic fat accumulation in pediatric patients onset intestinal failure.

Cell death & disease

Xiao Y,Wang J,Yan W,Zhou K,Cao Y,Cai W

Thu Oct 12 00:00:00 EDT 2017

Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice.

Scientific reports

Zhang W,Zhong W,Sun Q,Sun X,Zhou Z

Mon Aug 21 00:00:00 EDT 2017

Dietary Fisetin Supplementation Protects Against Alcohol-Induced Liver Injury in Mice.

Alcoholism, clinical and experimental research

Sun Q,Zhang W,Zhong W,Sun X,Zhou Z

Sat Oct 01 00:00:00 EDT 2016

Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice.

Annals of the New York Academy of Sciences

Niewiadomski J,Zhou JQ,Roman HB,Liu X,Hirschberger LL,Locasale JW,Stipanuk MH

Fri Jan 01 00:00:00 EST 2016

Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice.

EMBO reports

Zidek LM,Ackermann T,Hartleben G,Eichwald S,Kortman G,Kiehntopf M,Leutz A,Sonenberg N,Wang ZQ,von Maltzahn J,Müller C,Calkhoven CF

Sat Aug 01 00:00:00 EDT 2015

Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration.

PloS one

Wang Y,Kou Y,Wang X,Cederbaum A,Wang R

Tue Jan 20 00:00:00 EST 2015

Expressional studies of the aldehyde oxidase (AOX1) gene during myogenic differentiation in C2C12 cells.

Biochemical and biophysical research communications

Kamli MR,Kim J,Pokharel S,Jan AT,Lee EJ,Choi I

Fri Aug 08 00:00:00 EDT 2014

Expressional studies of the aldehyde oxidase (AOX1) gene during myogenic differentiation in C2C12 cells.

Biochemical and biophysical research communications

Kamli MR,Kim J,Pokharel S,Jan AT,Lee EJ,Choi I

Fri Aug 08 00:00:00 EDT 2014

Dietary nicotinic acid supplementation ameliorates chronic alcohol-induced fatty liver in rats.

Alcoholism, clinical and experimental research

Li Q,Xie G,Zhang W,Zhong W,Sun X,Tan X,Sun X,Jia W,Zhou Z

Tue Jul 01 00:00:00 EDT 2014

Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.

Proceedings of the National Academy of Sciences of the United States of America

Haldar SM,Jeyaraj D,Anand P,Zhu H,Lu Y,Prosdocimo DA,Eapen B,Kawanami D,Okutsu M,Brotto L,Fujioka H,Kerner J,Rosca MG,McGuinness OP,Snow RJ,Russell AP,Gerber AN,Bai X,Yan Z,Nosek TM,Brotto M,Hoppel CL,Jain MK

Tue Apr 24 00:00:00 EDT 2012

Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice.

American journal of physiology. Gastrointestinal and liver physiology

Sun X,Tang Y,Tan X,Li Q,Zhong W,Sun X,Jia W,McClain CJ,Zhou Z

Thu Mar 01 00:00:00 EST 2012

A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity.

FEBS letters

Kassmann CM,Quintes S,Rietdorf J,Möbius W,Sereda MW,Nientiedt T,Saher G,Baes M,Nave KA

Thu Jul 21 00:00:00 EDT 2011

Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles.

PloS one

Guo Y,Zhang X,Huang J,Zeng Y,Liu W,Geng C,Li KW,Yang D,Wu S,Wei H,Han Z,Qian X,Jiang Y,He F

Wed Oct 28 00:00:00 EDT 2009

Bioinformatics

Protein Aliases: ACO; acyl-CoA oxidase 1, palmitoyl; acyl-CoA oxidase, straight-chain; acyl-Coenzyme A oxidase 1, palmitoyl; AOX; Palmitoyl-CoA oxidase; Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain; Peroxisomal acyl-coenzyme A oxidase 1; Peroxisomal fatty acyl-CoA oxidase; peroxisomal fatty acyl-coenzyme A oxidase; peroxisomal straight-chain Acyl-CoA oxidase; SCOX; Straight-chain acyl-CoA oxidase

Gene Aliases: ACOX; ACOX1; AOX; D130055E20Rik; PALMCOX; Paox; RATACOA1; SCOX

UniProt ID: (Human) Q15067, (Rat) P07872, (Mouse) Q9R0H0

Entrez Gene ID: (Human) 51, (Rat) 50681, (Mouse) 11430

Molecular Function: oxidoreductase