Proteintech

ACSL5 Polyclonal Antibody

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ACSL5 Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 15708-1-AP (ACSL5 antibody) at dilution of 1:1200 incubated at room temperature for 1.5 hours.

ACSL5 Antibody in Immunoprecipitation (IP) — IP result of anti-ACSL5 (IP:15708-1-AP, 4ug; Detection:15708-1-AP 1:600) with mouse brain tissue lysate 4000ug.

Product Details

15708-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 12 publications 12 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ACSL5 Fusion Protein Ag8258 (388-739 aa encoded by BC007985)

Conjugate

Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

Immunogen sequence: DIRLLADDM KTLKPTLFPA VPRLLNRIYD KVQNEAKTPL KKFLLKLAVS SKFKELQKGI IRHDSFWDKL IFAKIQDSLG GRVRVIVTGA APMSTSVMTF FRAAMGCQVY EAYGQTECTG GCTFTLPGDW TSGHVGVPLA CNYVKLEDVA DMNYFTVNNE GEVCIKGTNV FKGYLKDPEK TQEALDSDGW LHTGDIGRWL PNGTLKIIDR KKNIFKLAQG EYIAPEKIEN IYNRSQPVLQ IFVHGESLRS SLVGVVVPDT DVLPSFAAKL GVKGSFEELC QNQVVREAIL EDLQKIGKES GLKTFEQVKA IFLHPEPFSI ENGLLTPTLK AKRGELSKYF RTQIDSLYEH IQD (388-739 aa encoded by BC007985)

Target Information

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Ye W,Wang J,Huang J,He X,Ma Z,Li X,Huang X,Li F,Huang S,Pan J,Jin J,Ling Q,Wang Y,Yu Y,Sun J,Jin J

Wed May 03 00:00:00 EDT 2023

Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance.

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Li H,Du Y,Ji H,Yang Y,Xu C,Li Q,Ran L,Wu C,Zhou Q,Wu S

Fri Nov 18 00:00:00 EST 2022

Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance.

iScience

Li H,Du Y,Ji H,Yang Y,Xu C,Li Q,Ran L,Wu C,Zhou Q,Wu S

Fri Nov 18 00:00:00 EST 2022

N⁶-methyladenosine (m⁶A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation.

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Ionic Liquid-Based Extraction System for In-Depth Analysis of Membrane Protein Complexes.

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Chu H,Zhao Q,Liu J,Yang K,Wang Y,Liu J,Zhang K,Zhao B,He H,Zheng Y,Zhong S,Liang Z,Zhang L,Zhang Y

Tue Jan 18 00:00:00 EST 2022

Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation.

Journal of proteome research

Zhou L,Wang Z,Hu C,Zhang C,Kovatcheva-Datchary P,Yu D,Liu S,Ren F,Wang X,Li Y,Hou X,Piao H,Lu X,Zhang Y,Xu G

Fri Mar 01 00:00:00 EST 2019

Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation.

Journal of proteome research

Zhou L,Wang Z,Hu C,Zhang C,Kovatcheva-Datchary P,Yu D,Liu S,Ren F,Wang X,Li Y,Hou X,Piao H,Lu X,Zhang Y,Xu G

Fri Mar 01 00:00:00 EST 2019

Expression Analysis of ACSL5 and Wnt2B in Human Congenital Pulmonary Airway Malformations.

The Journal of surgical research

Qu Y,Liu D,Jia H,Zhou X

Sat Dec 01 00:00:00 EST 2018

Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate.

Nature communications

Li TY,Song L,Sun Y,Li J,Yi C,Lam SM,Xu D,Zhou L,Li X,Yang Y,Zhang CS,Xie C,Huang X,Shui G,Lin SY,Reue K,Lin SC

Tue May 15 00:00:00 EDT 2018

Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate.

Nature communications

Li TY,Song L,Sun Y,Li J,Yi C,Lam SM,Xu D,Zhou L,Li X,Yang Y,Zhang CS,Xie C,Huang X,Shui G,Lin SY,Reue K,Lin SC

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Luo H,Jiang M,Lian G,Liu Q,Shi M,Li TY,Song L,Ye J,He Y,Yao L,Zhang C,Lin ZZ,Zhang CS,Zhao TJ,Jia WP,Li P,Lin SY,Lin SC

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AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.

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Luo H,Jiang M,Lian G,Liu Q,Shi M,Li TY,Song L,Ye J,He Y,Yao L,Zhang C,Lin ZZ,Zhang CS,Zhao TJ,Jia WP,Li P,Lin SY,Lin SC

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Scientific reports

Liu M,Xu L,Yin L,Qi Y,Xu Y,Han X,Zhao Y,Sun H,Yao J,Lin Y,Liu K,Peng J

Thu Jan 22 00:00:00 EST 2015

Potent effects of dioscin against obesity in mice.

Scientific reports

Liu M,Xu L,Yin L,Qi Y,Xu Y,Han X,Zhao Y,Sun H,Yao J,Lin Y,Liu K,Peng J

Thu Jan 22 00:00:00 EST 2015

Protective effects of dioscin against alcohol-induced liver injury.

Archives of toxicology

Xu T,Zheng L,Xu L,Yin L,Qi Y,Xu Y,Han X,Peng J

Sat Mar 01 00:00:00 EST 2014

Protective effects of dioscin against alcohol-induced liver injury.

Archives of toxicology

Xu T,Zheng L,Xu L,Yin L,Qi Y,Xu Y,Han X,Peng J

Sat Mar 01 00:00:00 EST 2014

Protective effects of dioscin against alcohol-induced liver injury.

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Xu T,Zheng L,Xu L,Yin L,Qi Y,Xu Y,Han X,Peng J

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The Journal of biological chemistry

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The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.

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Zhang S,Zheng L,Dong D,Xu L,Yin L,Qi Y,Han X,Lin Y,Liu K,Peng J

Sun Dec 01 00:00:00 EST 2013

Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats.

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Bioinformatics

Protein Aliases: Arachidonate--CoA ligase; FACL5 for fatty acid coenzyme A ligase 5; fatty acid coenzyme A ligase 5; fatty acid Coenzyme A ligase, long chain 5; fatty-acid-Coenzyme A ligase, long-chain 5; HGNC:16526; LACS 5; Long-chain acyl-CoA synthetase 5; long-chain fatty acid coenzyme A ligase 5; Long-chain-fatty-acid--CoA ligase 5

Gene Aliases: 1700030F05Rik; ACS2; ACS5; ACSL5; FACL5; UNQ633/PRO1250

UniProt ID: (Human) Q9ULC5, (Rat) O88813, (Mouse) Q8JZR0

Entrez Gene ID: (Human) 51703, (Rat) 94340, (Mouse) 433256

Molecular Function: immunoglobulin ligase