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Invitrogen
ACTA1/ACTA2/ACTC1 Polyclonal Antibody
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Product Details
PA5-100907
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ACTA1(Accession P68133), corresponding to amino acid residues M1-P34.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ACTA1/A2/C1.
Target Information
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACTA1; ACTA2; ACTC; actin alpha 1; actin alpha cardiac; actin alpha cardiac 1; actin, alpha 2, smooth muscle, aorta; Actin, alpha cardiac muscle 1; Actin, alpha skeletal muscle; actin, alpha, cardiac 1; actin, alpha, vascular smooth muscle; Actin, aortic smooth muscle; alpha-actin; alpha-actin cardiac; Alpha-actin-1; Alpha-actin-2; Alpha-cardiac actin; alphac-actin; Cell growth-inhibiting gene 46 protein; GIG46; nemaline myopathy type 3; smooth muscle alpha-actin; unnamed protein product
Gene Aliases: 0610041G09Rik; a-SMA; AA959943; ACTA; Acta-2; ACTA1; ACTA2; ACTC; Actc-1; ACTC1; Acts; ACTSA; Actsk-1; ACTVS; alphaSMA; ASD5; ASMA; CFTD; CFTD1; CFTDM; CMD1R; CMH11; CMYO2A; CMYO2B; CMYO2C; CMYP2A; CMYP2B; CMYP2C; GIG46; LVNC4; MPFD; NEM1; NEM2; NEM3; SHPM; SMalphaA; SMDYS
UniProt ID: (Human) P68133, (Human) P62736, (Human) P68032, (Mouse) P68134, (Rat) P68136, (Rat) P62738, (Mouse) P62737, (Mouse) P68033, (Rat) P68035
Entrez Gene ID: (Human) 58, (Human) 59, (Human) 70, (Mouse) 11459, (Rat) 29437, (Rat) 81633, (Mouse) 11475, (Mouse) 11464, (Rat) 29275
muscle contraction
positive regulation of gene expression
skeletal muscle thin filament assembly
skeletal muscle fiber development
mesenchyme migration
regulation of blood pressure
response to virus
vascular smooth muscle contraction
positive regulation of hepatic stellate cell migration
positive regulation of hepatic stellate cell contraction
positive regulation of ERK1 and ERK2 cascade
cellular response to transforming growth factor beta stimulus
juxtaglomerular apparatus development
glomerular mesangial cell development
positive regulation of hepatic stellate cell activation
actin filament organization
response to xenobiotic stimulus
actin filament-based movement
actomyosin structure organization
actin-myosin filament sliding
negative regulation of apoptotic process
response to ethanol
cardiac myofibril assembly
cardiac muscle tissue morphogenesis
heart contraction
cardiac muscle contraction
cytoplasmic actin-based contraction involved in cell motility
response to mechanical stimulus
response to extracellular stimulus
response to lithium ion
cell growth
skeletal muscle fiber adaptation
response to steroid hormone
metabolic process
actin-mediated cell contraction
response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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