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Abnova
ACTN1 Monoclonal Antibody (3F1)
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Product Details
H00000087-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG3, kappa
Class
Monoclonal
Type
Antibody
Clone
3F1
Immunogen
ACTN1 (NP_001093, 543 a.a. approximately 639 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: EIQGLTTAHE QFKATLPDAD KERLAILGIH NEVSKIVQTY HVNMAGTNPY TTITPQEING KWDHVRQLVP RRDQALTEEH ARQQHNERLR KQFGAQA
Target Information
Alpha Actinin 1 belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: actinin 1 smooth muscle; Alpha-actinin cytoskeletal isoform; Alpha-actinin-1; epididymis secretory sperm binding protein; F-actin cross-linking protein; FLJ40884; FLJ54432; Non-muscle alpha-actinin-1; unnamed protein product
Gene Aliases: ACTN1; BDPLT15
UniProt ID: (Human) P12814
Entrez Gene ID: (Human) 87
transcription coactivator activity
double-stranded RNA binding
actin binding
integrin binding
calcium ion binding
protein binding
cytoskeletal protein binding
vinculin binding
identical protein binding
protein homodimerization activity
ion channel binding
metal ion binding
actin filament binding
structural constituent of postsynapse
actin filament organization
actin cytoskeleton organization
platelet activation
platelet formation
platelet morphogenesis
regulation of apoptotic process
positive regulation of transcription, DNA-templated
focal adhesion assembly
anatomical structure formation involved in morphogenesis
actin filament bundle assembly
actin filament network formation
muscle cell development
platelet aggregation
postsynapse organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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