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Proteintech
ACTN3 Polyclonal Antibody
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Product Details
24378-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ACTN3 Fusion Protein Ag19479 (577-624 aa encoded by BC099647)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Amount
46.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RERGAIMGI QGEIQKICQT YGLRPCSTNP YITLSPQDIN TKWDMVRKL (577-624 aa encoded by BC099647)
Target Information
Alpha-actinin-3, also known as alpha-actinin skeletal muscle isoform 3 or F-actin cross-linking protein, is a protein that in humans is encoded by the ACTN3 gene. This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the coding allele.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Actinin alpha3; Actinin-alpha3; alpha-actinin skeletal muscle; Alpha-actinin skeletal muscle isoform 3; Alpha-actinin-3; alpha-Actinin3; alphaActinin-3; F-actin cross-linking protein; unnamed protein product
Gene Aliases: ACTN3; ACTN3D
UniProt ID: (Human) Q08043, (Mouse) O88990
Entrez Gene ID: (Human) 89, (Mouse) 11474
regulation of the force of skeletal muscle contraction
skeletal muscle atrophy
transition between fast and slow fiber
response to denervation involved in regulation of muscle adaptation
actin cytoskeleton organization
positive regulation of fast-twitch skeletal muscle fiber contraction
regulation of apoptotic process
negative regulation of glycolytic process
focal adhesion assembly
positive regulation of skeletal muscle tissue growth
positive regulation of skeletal muscle fiber development
muscle cell development
bone morphogenesis
negative regulation of calcineurin-NFAT signaling cascade
regulation of muscle system process
negative regulation of oxidative phosphorylation
negative regulation of cold-induced thermogenesis
positive regulation of bone mineralization involved in bone maturation
negative regulation of relaxation of muscle
regulation of aerobic respiration
positive regulation of glucose catabolic process to lactate via pyruvate
muscle contraction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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