Invitrogen

ACVR1 Polyclonal Antibody

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ACVR1 Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of paraffin embedded of Human Testis using Product # PA5-18842 at a concentration of 4 µg/mL. The tissue was processed by steamed antigen retrieval with citrate buffer pH 6 and stained with AP.

ACVR1 Antibody in Western Blot (WB) — Western Blot staining of Human Umbilical Cord lysate using Product # PA5-18842 at a concentration of 0.3 µg/mL, the primary antibody incubation was 1 hour and the detection method was chemiluminescence.

Product Details

PA5-18842

Applications	Tested Dilution	Publications
Western Blot (WB)	0.3-1 µg/mL	-
Immunohistochemistry (IHC)	4-6 µg/mL	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Goat / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Synthetic peptide sequence (RKFKRRNQERLNPRD) corresponding to the internal amino acids of ACVR1 View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.5 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	TBS, pH 7.3, with 0.5% BSA
Contains	0.02% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_10982402

Product Specific Information

This antibody is predicted to react with canine, mouse and rat based on sequence homology.

Target Information

The TGF-beta superfamily of ligands exerts its biological activity by binding to heteromeric receptor complexes two types (I and II) of the serine/threonine kinases. ALK1, like the other type I receptors, contains a cysteine rich domain with conserved cysteine spacing in the extracellular region and a glycine and serine rich domain preceding the kinase domain. The reduced human ALK1 monomer has a calculated molecular mass of approximately 37.3 kDa. Due to glycoslyation, the recombinant human protein migrates as a 50-55 kDa protein in SDS-PAGE under reducing conditions. Human and mouse ALK1 share approximately 71% amino acid sequence identity in their extracellular domains. ALK1 is highly expressed in endothelial cells and other vascular tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activin A receptor type I; activin A receptor, type I; activin A receptor, type II-like kinase 2; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; ACTR-I; ALK-2; hydroxyalkyl-protein kinase; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I

Gene Aliases: ACTRI; ACVR1; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI

UniProt ID: (Human) Q04771

Entrez Gene ID: (Human) 90

Molecular Function: serine/threonine protein kinase receptor