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Invitrogen
ADAM8 Polyclonal Antibody
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Product Details
PA5-27082
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide encompassing a sequence within the Intracellular domain of human ADAM8. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: Raji.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metalloproteinase; a disintegrin and metalloproteinase domain 8; ADAM; ADAM 8; ADAMs; CD156a; Cell surface antigen MS2; Disintegrin and metalloproteinase domain-containing protein 8; human leukocyte differentiation antigen; metalloendopeptidases; MGC134985; unnamed protein product
Gene Aliases: ADAM8; CD156; CD156a; MS2
UniProt ID: (Human) P78325
Entrez Gene ID: (Human) 101
metalloendopeptidase activity
serine-type endopeptidase activity
calcium ion binding
protein binding
peptidase activity
metallopeptidase activity
zinc ion binding
hydrolase activity
tumor necrosis factor receptor superfamily binding
immunoglobulin receptor binding
metal ion binding
cell adhesion molecule binding
cell morphogenesis
angiogenesis
leukocyte migration involved in inflammatory response
positive regulation of acute inflammatory response
positive regulation of cellular extravasation
proteolysis
inflammatory response
I-kappaB kinase/NF-kappaB signaling
positive regulation of epithelial to mesenchymal transition
positive regulation of protein processing
regulation of cell-cell adhesion
extracellular matrix disassembly
signal release
positive regulation of T cell differentiation in thymus
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of innate immune response
positive regulation of bone resorption
positive regulation of cell adhesion
lymphocyte chemotaxis
positive regulation of protein secretion
positive regulation of inflammatory response
positive regulation of membrane protein ectodomain proteolysis
positive regulation of protein kinase B signaling
positive regulation of thymocyte apoptotic process
cellular response to hypoxia
cell-cell adhesion
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
positive regulation of neutrophil extravasation
positive regulation of T cell migration
positive regulation of fibronectin-dependent thymocyte migration
positive regulation of eosinophil migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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