Invitrogen

ADAM8 Polyclonal Antibody

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ADAM8 Polyclonal Antibody

Product Details

PA5-87946

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human ADAM8 (NP_0011003)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.336 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2804528

Product Specific Information

Positive Samples: BxPC-3, NIH/3T3; Cellular Location: Membrane, Single-pass type I membrane protein

Immunogen sequence: IAPSRPWALM EQYEVVLPWR LPGPRVRRAL PSHLGLHPER VSYVLGATGH NFTLHLRKNR DLLGSGYTET YTAANGSEVT EQPRGQDHCF YQGHVEGYPD SAASLSTCAG LRGFFQVGSD LHLIEPLDEG GEGGRHAVYQ AEHLLQTAGT CGVSDDSLGS LLGPRTAAVF RPRPGDSLPS RETRYVELYV VVDNAEFQML GSEAAVRHRV LEVVNHVDKL YQKLNFRVVL VGLEIWNSQD RFHVSPDPSV TLENLLTWQA RQRTRRHLHD NVQLITGVDF TGTT

Target Information

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: a disintegrin and metallopeptidase domain 8; a disintegrin and metalloproteinase; a disintegrin and metalloproteinase domain 8; ADAM; ADAM 8; ADAM metallopeptidase domain 8; ADAMs; CD156a; Cell surface antigen MS2; Disintegrin and metalloproteinase domain-containing protein 8; human leukocyte differentiation antigen; Macrophage cysteine-rich glycoprotein; metalloendopeptidases; MGC134985

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Gene Aliases: ADAM 8; ADAM8; CD156; CD156a; E430039A18Rik; MS2; RGD1566394

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UniProt ID: (Human) P78325, (Mouse) Q05910

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Entrez Gene ID: (Human) 101, (Mouse) 11501, (Rat) 499285

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Function(s)
metalloendopeptidase activity serine-type endopeptidase activity calcium ion binding protein binding metallopeptidase activity zinc ion binding protein self-association cell adhesion molecule binding molecular_function metalloprotease
Process(es)
cell morphogenesis angiogenesis leukocyte migration involved in inflammatory response positive regulation of acute inflammatory response proteolysis inflammatory response positive regulation of protein processing single organismal cell-cell adhesion regulation of cell-cell adhesion extracellular matrix disassembly positive regulation of T cell differentiation in thymus activation of MAPK activity involved in innate immune response negative regulation of neuron apoptotic process positive regulation of bone resorption positive regulation of cell adhesion lymphocyte chemotaxis positive regulation of protein secretion positive regulation of membrane protein ectodomain proteolysis positive regulation of NF-kappaB transcription factor activity positive regulation of protein kinase B signaling positive regulation of thymocyte apoptotic process cellular response to hypoxia positive regulation of tumor necrosis factor (ligand) superfamily member 11 production positive regulation of neutrophil extravasation positive regulation of fibronectin-dependent thymocyte migration positive regulation of eosinophil migration positive regulation of cellular extravasation biological_process positive regulation of inflammatory response positive regulation of T cell migration
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