Immunogen sequence: QAGNEEMVQI DLPIKRYREY ELVTPVSTNL EGRYLSHTLS ASHKKRSARD VSSNPEQLFF NITAFGKDFH LRLKPNTQL
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 84%.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 3; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 3; ADAM; ADAM metallopeptidase with thrombospondin type 1 motif, 3; ADAM-TS 3; ADAM-TS3; ADAMs; ADAMTS-3; metalloendopeptidases; PC II-NP; Procollagen II amino propeptide-processing enzyme; Procollagen II N-proteinase; zinc metalloendopeptidase
Gene Aliases: ADAMTS-4; ADAMTS3; KIAA0366
UniProt ID: (Human) O15072
Entrez Gene ID: (Human) 9508
Molecular Function: metalloprotease