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Proteintech
ADAMTS4 Polyclonal Antibody
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Product Details
11865-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ADAMTS4 Fusion Protein Ag2443
Conjugate
Form
Liquid
Concentration
233 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
This gene encodes a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 4; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; ADAM; ADAM-TS 4; ADAM-TS4; ADAMs; ADAMTS-4; ADAMTS4 alternative splice variant; ADMP-1; aggrecan degrading metalloproteinase-1; disintegrin metalloproteinase; Aggrecanase 1; Aggrecanase-1; epididymis secretory sperm binding protein; metalloendopeptidases; unnamed protein product
Gene Aliases: 3830423K05; ADAM-TS4; ADAMTS-2; ADAMTS-4; ADAMTS4; ADMP-1; KIAA0688; mKIAA0688; UNQ769/PRO1563
UniProt ID: (Human) O75173, (Mouse) Q8BNJ2
Entrez Gene ID: (Human) 9507, (Mouse) 240913
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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