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ADAMTS4 Polyclonal Antibody
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Product Details
BS-4191R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human ADAMTS4, amino acids 501-839.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metallopeptidase with thrombospondin motifs 4; a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 4; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; ADAM; ADAM-TS 4; ADAM-TS4; ADAMs; ADAMTS-4; ADAMTS4 alternative splice variant; ADMP-1; aggrecan degrading metalloproteinase-1; disintegrin metalloproteinase; Aggrecanase; Aggrecanase 1; Aggrecanase-1; epididymis secretory sperm binding protein; metalloendopeptidases; unnamed protein product
Gene Aliases: 3830423K05; ADAM-TS4; ADAMTS-2; ADAMTS-4; ADAMTS4; ADMP-1; KIAA0688; mKIAA0688; UNQ769/PRO1563
UniProt ID: (Human) O75173, (Mouse) Q8BNJ2, (Rat) Q9ESP7
Entrez Gene ID: (Human) 9507, (Mouse) 240913, (Rat) 66015
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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