Synthetic peptide sequence: 813-837aa, TPQDWLHRRAQILEILRRRPWAGRK.
Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
This gene encodes a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 4; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; ADAM; ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADAM-TS 4; ADAM-TS4; ADAMs; ADMP-1; Aggrecanase 1; Aggrecanase-1; metalloendopeptidases
Gene Aliases: ADAMTS-2; ADAMTS-4; ADAMTS4; ADMP-1; KIAA0688; UNQ769/PRO1563
UniProt ID: (Human) O75173
Entrez Gene ID: (Human) 9507
Molecular Function: metalloprotease