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Invitrogen
ADAMTS7 Polyclonal Antibody
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Product Details
PA5-103583
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ADAMTS7(Accession Q9UKP4), corresponding to amino acid residues R1514-P1564.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ADAMTS7.
Target Information
ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an N-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a C-terminus that contains a varying number of thrombospondin type-1 (TSP-1) motifs. ADAMTS genes are primarily expressed in fetal tissues, including lung, kidney and liver. ADAMTS-7 (ADAM metallopeptidase with thrombospondin type 1 motif, 7), also known as COMPase, is a 1,686 amino acid protein that exists as two alternatively spliced isoforms. Encoded by a gene that maps to human chromosome 15q25.1, ADAMTS-7 contains eight TSP-1 motifs and binds one zinc ion per subunit. ADAMTS-7 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. ADAMTS-7 is also located in meniscus, bone, tendon, cartilage, synovium, fat and ligaments, and is up-regulated in articular cartilage and synovium in arthritis patients. ADAMTS-7 functions as a metalloprotease and may play a role in the degradation of COMP. ADAMTS-7 is pH dependent, with optimum pH between 7.5 and 9.5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metalloprotease with thrombospondin motifs-7 preproprotein; a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 7; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7; ADAM; ADAM-TS 7; ADAMs; COMPase; metalloendopeptidases; metalloproteinase; unnamed protein product
Gene Aliases: ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7
UniProt ID: (Human) Q9UKP4
Entrez Gene ID: (Human) 11173
ossification
chondrocyte differentiation
proteoglycan metabolic process
proteolysis
extracellular matrix organization
collagen fibril organization
negative regulation of chondrocyte differentiation
ossification involved in bone maturation
proteolysis involved in cellular protein catabolic process
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to BMP stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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