Immunogen sequence: MVQAWYMDDA PGDPRQPHRP DPGRPVGLEQ LRRLGVLYWK LDADKYENDP ELEKIRRERN YSWMDIITIC KDKLPNYEEK IKMFYEEHLH LDDEIRYILD GSGYFDVRDK EDQWIRIFME KGDMVTLPAG IYHRFTVDEK NYTKAMRLFV GEPVWTAYNR PADHFEARGQ YVKFLAQTA; Positive Samples: U-87MG, A-549, SGC7901, HT-29, 293T, HepG2; Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic side, Nucleus, Peripheral membrane protein
This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. A pseudogene that is located on chromosome 20 has been defined for this gene.
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Protein Aliases: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Acireductone dioxygenase (Fe(2+)-requiring); acireductone dioxygenase (Ni(2+)-requiring); ARD; membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1; Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1; MT1-MMP cytoplasmic tail-binding protein-1; MTCBP-1; Sip-L; submergence induced protein 2; Submergence-induced protein-like factor
Gene Aliases: ADI1; APL1; ARD; Fe-ARD; HMFT1638; MTCBP1; mtnD; Ni-ARD; SIPL
UniProt ID: (Human) Q9BV57
Entrez Gene ID: (Human) 55256
Molecular Function: oxidoreductase