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Invitrogen
ADNP Polyclonal Antibody
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FIGURE: 1 / 2
ADNP Antibody (PA5-113482) in IHC (P)
Immunocytochemical analysis of paraffin-embeded ADNP in human brain tissue using a ADNP polyclonal antibody (Product # PA5-113482) at a dilution of 1:200. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). The section was blocked with 10% normal goat serum for 30 min at room temperature. The primary antibody, in 1% BSA, was incubated at 4°C overnight.... View More
Product Details
PA5-113482
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Activity-dependent neuroprotector homeobox protein (867-1102AA)
Conjugate
Form
Liquid
Concentration
2.17 mg/mL
Amount
217 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activity-dependent neuroprotective protein; activity-dependent neuroprotector; Activity-dependent neuroprotector homeobox protein; ADNP; ADNP homeobox 1; unnamed protein product
Gene Aliases: ADNP; ADNP1; HVDAS; KIAA0784; MRD28
UniProt ID: (Human) Q9H2P0
Entrez Gene ID: (Human) 23394
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
chromatin binding
copper ion binding
protein binding
beta-catenin binding
zinc ion binding
peptide binding
metal ion binding
beta-tubulin binding
regulation of transcription from RNA polymerase II promoter
short-term memory
response to carbohydrate
regulation of gene expression
negative regulation of gene expression
positive regulation of neuron projection development
cGMP-mediated signaling
neuron differentiation
nitric oxide homeostasis
negative regulation of neuron apoptotic process
estrous cycle
positive regulation of axon extension
negative regulation of synaptic transmission
neuron apoptotic process
positive regulation of synapse assembly
positive regulation of canonical Wnt signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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