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Invitrogen
ADSL Polyclonal Antibody
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FIGURE: 1 / 4
ADSL Antibody (PA5-87207) in IHC (P)
Immunohistochemistry analysis of ADSL in paraformaldehyde-fixed, paraffin embedded Human kidney. Samples were incubated with ADSL polyclonal antibody (Product # PA5-87207) using a dilution of 1:200 overnight at 4°C. Antigen retrieval by boiling in sodium citrate buffer (pH 6.0) for 15 min. Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes. Blocking buffer (normal goat serum) at 37°C for 30 ... View More
Product Details
PA5-87207
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Adenylosuccinate Lyase: 185-280.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
ADSL (adenylosuccinate lyase), also known as AMPS, ASL or ASASE, is a 484 amino acid protein that is involved in both purine biosynthesis and in the formation of adenosine monophosphate (AMP) from inosine monophosphate. Expressed ubiquitously, ADSL catalyzes two key reactions in AMP biosynthesis, namely the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and the subsequent removal of fumarate from adenylosuccinate to yield AMP. Defects in the gene encoding ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency), an autosomal recessive disorder characterized by epilepsy, growth retardation and muscular wasting. Multiple isoforms of ADSL exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adenylosuccinase; Adenylosuccinate lyase; adenylosuccinate lyase 1; ADSL; ASase; ASL; test
Gene Aliases: Adl; ADSL; AMPS; ASASE; ASL; null
UniProt ID: (Human) P30566, (Mouse) P54822
Entrez Gene ID: (Human) 158, (Rat) 315150, (Mouse) 11564
purine nucleotide biosynthetic process
AMP biosynthetic process
'de novo' IMP biosynthetic process
purine ribonucleoside monophosphate biosynthetic process
'de novo' AMP biosynthetic process
protein tetramerization
response to hypoxia
purine nucleotide metabolic process
response to nutrient
metabolic process
aerobic respiration
ribonucleoside monophosphate biosynthetic process
response to muscle activity
response to starvation
purine ribonucleotide biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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