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Invitrogen
ADSL Polyclonal Antibody
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Product Details
PA5-97439
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Adenylosuccinate lyase protein (1-310AA)
Conjugate
Form
Liquid
Concentration
0.47 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
ADSL (adenylosuccinate lyase), also known as AMPS, ASL or ASASE, is a 484 amino acid protein that is involved in both purine biosynthesis and in the formation of adenosine monophosphate (AMP) from inosine monophosphate. Expressed ubiquitously, ADSL catalyzes two key reactions in AMP biosynthesis, namely the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and the subsequent removal of fumarate from adenylosuccinate to yield AMP. Defects in the gene encoding ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency), an autosomal recessive disorder characterized by epilepsy, growth retardation and muscular wasting. Multiple isoforms of ADSL exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adenylosuccinase; Adenylosuccinate lyase; adenylosuccinate lyase 1; ADSL; alternatively spliced; ASase; ASL; unnamed protein product
Gene Aliases: Adl; ADSL; AMPS; ASASE; ASL
UniProt ID: (Human) P30566, (Mouse) P54822
Entrez Gene ID: (Human) 158, (Mouse) 11564
response to hypoxia
purine nucleotide biosynthetic process
AMP biosynthetic process
GMP biosynthetic process
'de novo' IMP biosynthetic process
response to nutrient
aerobic respiration
purine ribonucleotide biosynthetic process
response to muscle activity
response to starvation
'de novo' AMP biosynthetic process
AMP salvage
'de novo' XMP biosynthetic process
purine nucleotide metabolic process
metabolic process
ribonucleoside monophosphate biosynthetic process
protein tetramerization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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