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AFG3L2 Polyclonal Antibody
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FIGURE: 1 / 3
AFG3L2 Antibody (PA5-90436) in IHC (P)
Immunohistochemistry analysis of AFG3L2 in paraffin-embedded human colon carcinoma. Samples were incubated with AFG3L2 Polyclonal antibody (Product # PA5-90436) using a dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-90436
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.48 mg/mL
Amount
48 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DSINQKHFEQ AIERVIGGLE KKTQVLQPEE KKTVAYHEAG HAVAGWYLEH ADPLLKVSII PRGKGLGYAQ YLPKEQYLYT KEQLLDRMCM TLGGRVSEEI FFGRITTGAQ DDLRKVTQSA YAQIVQFGMN EKVGQISFDL PRQGDMVLEK PYSEATARLI DDEVRILIND AYKRTVALLT EKKADVEKVA LLLLEKEVLD KNDMVELLGP RPFAEKSTYE EFVEGTGSLD EDTSLPEGLK DWNKEREKEK EEPPGEKVAN; Positive Samples: LO2, 293T, HeLa, Mouse brain, Mouse heart, Mouse kidney, Mouse liver, Mouse pancreas; Cellular Location: Mitochondrion membrane, Multi-pass membrane protein
Target Information
AFG3L2 is a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. AFG3L2 gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders. This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AFG3 (ATPase family gene 3)-like 2; AFG3 ATPase family gene 3-like 2; AFG3 ATPase family member 3-like 2; AFG3 like AAA ATPase 2; AFG3-like AAA ATPase 2; AFG3-like protein 2; ATPase family gene 3, yeast; FLJ25993; paraplegin-like protein; unnamed protein product
Gene Aliases: 2310036I02Rik; Emv66; OPA12; par; SCA28; SPAX5
UniProt ID: (Human) Q9Y4W6, (Mouse) Q8JZQ2
Entrez Gene ID: (Human) 10939, (Rat) 307350, (Mouse) 69597
proteolysis
mitochondrion organization
axonogenesis
neuromuscular junction development
mitochondrial fusion
biological_process
protein processing
protein autoprocessing
nerve development
protein catabolic process
membrane protein proteolysis
mitochondrial protein processing
calcium ion transmembrane import into mitochondrion
regulation of multicellular organism growth
cristae formation
myelination
mitochondrial calcium ion homeostasis
protein maturation
muscle cell development
righting reflex
cellular response to glutathione
regulation of calcium import into the mitochondrion
mitochondrial protein quality control
glutathione import into mitochondrion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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