IEF2C1 and 2 are members of the Argonaute family. These proteins are involved in short-interfering-RNA-mediated gene silencing. This process is mediated by the RISC (RNA induced silencing complex), a multicomponent nuclease that is able to degrade double stranded RNAs. The mRNA degradation is triggered by the association of specific siRNAs with their homologous mRNAs. IEF2C2 has been shown to be essential for embryonic development.
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Protein Aliases: argonaute 1; argonaute 2; Argonaute RISC catalytic component 1; Argonaute RISC catalytic component 2; Argonaute1; Argonaute2; CTA-204B4.6; eIF-2C 1; eIF-2C 2; eIF2C 1; eIF2C 2; Eukaryotic translation initiation factor 2C 1; Eukaryotic translation initiation factor 2C 2; eukaryotic translation initiation factor 2C, 1; eukaryotic translation initiation factor 2C, 2; Golgi Endoplasmic Reticulum protein 95 kDa; hAgo2; PAZ Piwi domain protein; PPD; Protein argonaute-1; Protein argonaute-2; Protein slicer; Putative RNA-binding protein Q99
Gene Aliases: AGO1; AGO2; EIF2C; EIF2C1; EIF2C2; GERP95; hAgo1; Q10; Q99