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Invitrogen
AGO1/AGO2 Polyclonal Antibody
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FIGURE: 1 / 2
AGO1/AGO2 Antibody (PA5-40075) in WB
Whole cell extracts of U2OS cells (40 µg) were analyzed by Western Blot using a AGO1 + AGO2 polyclonal antibody (Product # PA5-40075) at a dilution of 1:1,000 in TBS-Tween containing 5% skimmed milk. The position of the protein of interest is indicated on the right (expected size: 97 kDa); the marker (kDa) is shown on the left.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-40075
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH-conjugated synthetic peptide containing a sequence from the C-terminal part of both EIF2C1 and EIF2C2 corresponding to human IEF2C1/2 (eukaryotic translation initiation factor 2C1 and 2).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
IEF2C1 and 2 are members of the Argonaute family. These proteins are involved in short-interfering-RNA-mediated gene silencing. This process is mediated by the RISC (RNA induced silencing complex), a multicomponent nuclease that is able to degrade double stranded RNAs. The mRNA degradation is triggered by the association of specific siRNAs with their homologous mRNAs. IEF2C2 has been shown to be essential for embryonic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: argonaute 1, RISC catalytic component; argonaute 2, RISC catalytic component; argonaute RISC catalytic component 1; argonaute1; cancer susceptibility candidate 7 (non-protein coding); eIF-2C 1; eIF2C 1; eukaryotic translation initiation factor 2C, 1; eukaryotic translation initiation factor 2C, 2; Golgi Endoplasmic Reticulum protein 95 kDa; long intergenic non-protein coding RNA 980; PAZ Piwi domain protein; protein slicer; putative RNA-binding protein Q99; unnamed protein product
Gene Aliases: CASC7; EIF2C; EIF2C1; EIF2C2; GERP95; hAgo1; LESKRES; LINC00980; NEDLBAS; PPD; Q10; Q99
UniProt ID: (Human) Q9UL18, (Human) Q9UKV8
Entrez Gene ID: (Human) 26523, (Human) 27161
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core binding
core promoter sequence-specific DNA binding
nucleic acid binding
RNA binding
double-stranded RNA binding
single-stranded RNA binding
endoribonuclease activity
protein binding
miRNA binding
RNA 7-methylguanosine cap binding
mRNA binding
translation initiation factor activity
endoribonuclease activity, producing 5'-phosphomonoesters
siRNA binding
mRNA 3'-UTR AU-rich region binding
endoribonuclease activity, cleaving siRNA-paired mRNA
endoribonuclease activity, cleaving miRNA-paired mRNA
mRNA cap binding
regulation of transcription, DNA-templated
translation
translational initiation
gene silencing by RNA
pre-miRNA processing
cytoplasmic mRNA processing body assembly
posttranscriptional gene silencing by RNA
production of miRNAs involved in gene silencing by miRNA
miRNA mediated inhibition of translation
mRNA cleavage involved in gene silencing by miRNA
negative regulation of amyloid precursor protein biosynthetic process
positive regulation of translation
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
negative regulation of translational initiation
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
small RNA loading onto RISC
regulation of synapse maturation
mRNA cleavage involved in gene silencing by siRNA
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of trophoblast cell migration
nuclear-transcribed mRNA catabolic process
negative regulation of angiogenesis
regulation of mRNA stability
positive regulation of NIK/NF-kappaB signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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