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Invitrogen

AGO1/AGO2 Polyclonal Antibody

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AGO1/AGO2 Polyclonal Antibody

Product Details

PA5-40075

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

ELISA (ELISA)

1:3,500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH-conjugated synthetic peptide containing a sequence from the C-terminal part of both EIF2C1 and EIF2C2 corresponding to human IEF2C1/2 (eukaryotic translation initiation factor 2C1 and 2).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2576597

Target Information

IEF2C1 and 2 are members of the Argonaute family. These proteins are involved in short-interfering-RNA-mediated gene silencing. This process is mediated by the RISC (RNA induced silencing complex), a multicomponent nuclease that is able to degrade double stranded RNAs. The mRNA degradation is triggered by the association of specific siRNAs with their homologous mRNAs. IEF2C2 has been shown to be essential for embryonic development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: argonaute 1, RISC catalytic component; argonaute 2, RISC catalytic component; Argonaute RISC catalytic component 1; Argonaute RISC catalytic component 2; Argonaute1; Argonaute2; cancer susceptibility candidate 7 (non-protein coding); eIF-2C 1; eIF-2C 2; eIF2C 1; Eukaryotic translation initiation factor 2C 1; Eukaryotic translation initiation factor 2C 2; eukaryotic translation initiation factor 2C, 1; eukaryotic translation initiation factor 2C, 2; Golgi Endoplasmic Reticulum protein 95 kDa; long intergenic non-protein coding RNA 980; PAZ Piwi domain protein; PPD; Protein argonaute-1; Protein argonaute-2; Protein slicer; Putative RNA-binding protein Q99; unnamed protein product

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Gene Aliases: AGO1; AGO2; CASC7; EIF2C; EIF2C1; EIF2C2; GERP95; hAgo1; LESKRES; LINC00980; NEDLBAS; PPD; Q10; Q99

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UniProt ID: (Human) Q5TA57, (Human) Q9UKV8

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Entrez Gene ID: (Human) 26523, (Human) 27161

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core binding core promoter sequence-specific DNA binding nucleic acid binding RNA binding double-stranded RNA binding single-stranded RNA binding endoribonuclease activity protein binding miRNA binding RNA 7-methylguanosine cap binding mRNA binding translation initiation factor activity nuclease activity endonuclease activity hydrolase activity endoribonuclease activity, producing 5'-phosphomonoesters siRNA binding mRNA 3'-UTR AU-rich region binding metal ion binding endoribonuclease activity, cleaving siRNA-paired mRNA endoribonuclease activity, cleaving miRNA-paired mRNA mRNA cap binding
Process(es)
regulation of transcription, DNA-templated translation translational initiation regulation of translation post-embryonic development gene expression miRNA metabolic process positive regulation of gene expression production of siRNA involved in RNA interference gene silencing by RNA pre-miRNA processing cytoplasmic mRNA processing body assembly posttranscriptional gene silencing by RNA production of miRNAs involved in gene silencing by miRNA miRNA mediated inhibition of translation mRNA cleavage involved in gene silencing by miRNA negative regulation of amyloid precursor protein biosynthetic process RNA stabilization positive regulation of translation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter negative regulation of translational initiation positive regulation of nuclear-transcribed mRNA poly(A) tail shortening small RNA loading onto RISC regulation of synapse maturation mRNA cleavage involved in gene silencing by siRNA positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of trophoblast cell migration nuclear-transcribed mRNA catabolic process negative regulation of angiogenesis regulation of mRNA stability positive regulation of NIK/NF-kappaB signaling
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