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Invitrogen
IL-10 Monoclonal Antibody (JES3-9D7)
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Product Details
AHC0102
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse,
Non-human primate,
Rat,
Rhesus monkey
Host/Isotype
Rat
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
JES3-9D7
Immunogen
Recombinant human Interleukin 10.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
500 µg
Purification
purified
Storage buffer
PBS, pH 7.2
Contains
no preservative
Storage conditions
-20°C
RRID
Target Information
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cytokine synthesis inhibitory factor; H-IL-10; il 10; IL10; ILN; Interleukin; Interleukin10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor
Gene Aliases: CSIF; GVHDS; IL-10; IL10A; TGIF
UniProt ID: (Human) P22301
Entrez Gene ID: (Human) 3586
negative regulation of cytokine production
positive regulation of cytokine production
positive regulation of endothelial cell proliferation
response to molecule of bacterial origin
positive regulation of immunoglobulin production
negative regulation of cytokine production involved in immune response
positive regulation of B cell apoptotic process
immune response
JAK-STAT cascade
positive regulation of cell proliferation
negative regulation of cell proliferation
response to xenobiotic stimulus
regulation of gene expression
negative regulation of autophagy
response to activity
response to inactivity
cytokine-mediated signaling pathway
hemopoiesis
B cell differentiation
leukocyte chemotaxis
negative regulation of B cell proliferation
response to lipopolysaccharide
negative regulation of interferon-alpha production
negative regulation of interleukin-1 production
negative regulation of interleukin-12 production
negative regulation of interleukin-18 production
negative regulation of interleukin-6 production
negative regulation of interleukin-8 production
negative regulation of tumor necrosis factor production
response to insulin
negative regulation of heterotypic cell-cell adhesion
positive regulation of heterotypic cell-cell adhesion
response to carbon monoxide
type 2 immune response
B cell proliferation
negative regulation of T cell proliferation
positive regulation of tyrosine phosphorylation of STAT protein
positive regulation of macrophage activation
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
negative regulation of nitric oxide biosynthetic process
T-helper 1 cell differentiation
regulation of isotype switching
negative regulation of MHC class II biosynthetic process
positive regulation of cell cycle
positive regulation of transcription, DNA-templated
negative regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JAK-STAT cascade
negative regulation of inflammatory response
regulation of synapse organization
regulation of B cell activation
negative regulation of membrane protein ectodomain proteolysis
response to glucocorticoid
negative regulation of cytokine activity
cellular response to lipopolysaccharide
cellular response to estradiol stimulus
negative regulation of chemokine (C-C motif) ligand 5 production
endothelial cell apoptotic process
liver regeneration
interleukin-10-mediated signaling pathway
positive regulation of plasma cell differentiation
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
regulation of response to wounding
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
regulation of complement-dependent cytotoxicity
positive regulation of sprouting angiogenesis
negative regulation of vascular smooth muscle cell proliferation
positive regulation of vascular smooth muscle cell proliferation
negative regulation of endothelial cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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