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Invitrogen
AID Polyclonal Antibody
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Product Details
PA5-28077
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human AICDA. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 40% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, HeLa, Raji.
Predicted reactivity: Chimpanzee (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activation induced deaminase; Activation-induced cytidine deaminase; AID; AID isoform AIDins(IVS3); Cytidine aminohydrolase; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos; Single-stranded DNA cytosine deaminase
Gene Aliases: AICDA; AID; ARP2; CDA2; HEL-S-284; HIGM2
UniProt ID: (Human) Q9GZX7, (Mouse) Q9WVE0
Entrez Gene ID: (Human) 57379, (Mouse) 11628
mRNA processing
regulation of macromolecule biosynthetic process
somatic diversification of immunoglobulins
somatic hypermutation of immunoglobulin genes
cytidine to uridine editing
B cell differentiation
regulation of nuclear cell cycle DNA replication
defense response to bacterium
hypomethylation of CpG island
isotype switching
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
defense response to virus
DNA cytosine deamination
cellular response to lipopolysaccharide
cytidine deamination
DNA demethylation
negative regulation of methylation-dependent chromatin silencing
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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