PA5-28077 targets AICDA in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-28077 immunogen is synthetic peptide corresponding to a region within amino acids 1 and 60 of Human AICDA.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2).
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Protein Aliases: Activation-induced cytidine deaminase; AID; ARP2; CDA2; Cytidine aminohydrolase; epididymis secretory protein Li 284; HIGM2; integrated into Burkitt's lymphoma cell line Ramos; Single-stranded DNA cytosine deaminase
Gene Aliases: AICDA; AID; ARP2; CDA2; HEL-S-284; HIGM2
UniProt ID: (Human) Q9GZX7
Entrez Gene ID: (Human) 57379