Search
Proteintech
AKAP12 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
25199-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AKAP12 Fusion Protein Ag17769 (1433-1782 aa encoded by BC157067)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Amount
42 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ETANILETG ETLEPAGAHL VLEEKSSEKN EDFAAHPGED AVPTGPDCQA KSTPVIVSAT TKKGLSSDLE GEKTTSLKWK SDEVDEQVAC QEVKVSVAIE DLEPENGILE LETKSSKLVQ NIIQTAVDQF VRTEETATEM LTSELQTQAH VIKADSQDAG QETEKEGEEP QASAQDETPI TSAKEESEST AVGQAHSDIS KDMSEASEKT MTVEVEGSTV NDQQLEEVVL PSEEEGGGAG TKSVPEDDGH ALLAERIEKS LVEPKEDEKG DDVDDPENQN SALADTDASG GLTKESPDTN GPKQKEKEDA QEVELQEGKV HSESDKAITP QAQEELQKQE RESAKSELTE S (1433-1782 aa encoded by BC157067)
Target Information
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: A kinase (PRKA) anchor protein (gravin) 12; A kinase (PRKA) anchor protein 12; A-kinase anchor protein 12; A-kinase anchor protein 250 kDa; A-kinase anchor protein, 250kDa; AKAP 250; AKAP-12; gercelin; Germ cell lineage protein gercelin; Gravin; kinase scaffold protein gravin; Myasthenia gravis autoantigen; myasthenia gravis autoantigen gravin; Src-Suppressed C Kinase Substrate; SSeCKS; SSeCKS, Gravin, AKAP250; testis specific gene A12; v-src suppressed transcript 5
Gene Aliases: AI317366; AKAP12; AKAP12A; AKAP12B; AKAP12G; AKAP250; Gag12; Srcs5; SSeCKS; Tsga12
UniProt ID: (Human) Q02952, (Mouse) Q9WTQ5, (Rat) Q5QD51
Entrez Gene ID: (Human) 9590, (Mouse) 83397, (Rat) 83425
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
regulation of protein kinase A signaling
positive regulation of protein kinase A signaling
response to lipopolysaccharide
positive regulation of tumor necrosis factor production
hepatic stellate cell activation
negative regulation of vascular permeability
modulation of synaptic transmission
response to electrical stimulus
positive regulation of hepatic stellate cell migration
positive regulation of ERK1 and ERK2 cascade
cellular response to interleukin-1
cellular response to tumor necrosis factor
regulation of protein kinase C signaling
positive regulation of oligodendrocyte apoptotic process
protein targeting
positive regulation of cAMP biosynthetic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support