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Proteintech
ALAS1 Polyclonal Antibody
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Product Details
16200-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ALAS1 Fusion Protein Ag9126 (1-330 aa encoded by BC011798)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MESVVRRCP FLSRVPQAFL QKAGKSLLFY AQNCPKMMEV GAKPAPRALS TAAVHYQQIK ETPPASEKDK TAKAKVQQTP DGSQQSPDGT QLPSGHPLPA TSQGTASKCP FLAAQMNQRG SSVFCKASLE LQEDVQEMNA VRKEVAETSA GPSVVSVKTD GGDPSGLLKN FQDIMQKQRP ERVSHLLQDN LPKSVSTFQY DRFFEKKIDE KKNDHTYRVF KTVNRRAHIF PMADDYSDSL ITKKQVSVWC SNDYLGMSRH PRVCGAVMDT LKQHGAGAGG TRNISGTSKF HVDLERELAD LHGKDAALLF SSCFVANDST LFTLAKMMPG C (1-330 aa encoded by BC011798)
Target Information
ALAS-1 is a nuclear-encoded mitochondrial matrix enzyme which catalyzes the condensation of glycine with succinyl-CoA to form delta-amino levulinate, CO2 and CoA. It regulates the first and rate-limiting step of heme biosynthetic pathway. It is one of the two isoforms of ALAS and is a pyridoxal-5' phosphate dependant housekeeping enzyme. It is ubiquitously expressed and is responsible of providing heme for cytochromes and other hemoproteins. ALAS1 in liver undergoes negative feedback regulation by heme. Transcription of ALAS1 gene is stimulated by cAMP and respiratory uncoupling whereas Phorbol esters and insulin repress ALAS1 gene expression. ALAS1 is suggested to be involved in reciprocal regulation of Heme biosynthesis and circadian clock suggesting a potential target for treatment of circadian disorders. ALAS1 gene expression is down regulated in Acute Liver failure resulting in altered heme metabolism and liver function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 5-aminolevulinate synthase 1; 5-aminolevulinate synthase, non-specific, mitochondrial; 5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinic acid synthase 1; ALA-S; ALAS-H; ALAS-N; aminolevulinate synthase H; aminolevulinate, delta-, synthase 1; aminolevulinic acid synthase 1; Delta-ALA synthase 1; delta-ALA synthetase; Delta-aminolevulinate synthase 1; migration-inducing protein 4; succinyl-CoA: glycine C-succinyl transferase
Gene Aliases: ALAS; Alas-1; ALAS-H; ALAS-N; ALAS1; ALAS3; ALASH; MIG4; OK/SW-cl.121
UniProt ID: (Human) P13196, (Rat) P13195, (Mouse) Q8VC19
Entrez Gene ID: (Human) 211, (Rat) 65155, (Mouse) 11655
protoporphyrinogen IX biosynthetic process
heme biosynthetic process
mitochondrion organization
response to hypoxia
response to herbicide
response to organic substance
response to nickel cation
response to organic cyclic compound
response to nutrient levels
response to cobalt ion
cellular response to insulin stimulus
response to gonadotropin
response to drug
response to ethanol
response to cAMP
response to platinum ion
cellular response to organic cyclic compound
porphyrin-containing compound metabolic process
metabolic process
biosynthetic process
tetrapyrrole biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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