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Invitrogen
ALDH1A1 Polyclonal Antibody
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Product Details
PA5-95937
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat,
Rodent
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 301-400 of human ALDH1A1 (NP_0006802)
Conjugate
Form
Liquid
Concentration
1.04 mg/mL
Amount
104 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: A-549, HT-29, K-562, Mouse liver, Mouse lung, Rat lung; Cellular Location: Cytoplasm
Immunogen sequence: KYILGNPLTP GVTQGPQ
Target Information
ALDH1A1 belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3-deoxyglucosone dehydrogenase; acetaldehyde dehydrogenase 1; alcohol dehydrogenase family 1, subfamily A1; alcohol dehydrogenase family 1, subfamily A2; aldehyde dehydrogenase 1 (EC 1.2.1.3); Aldehyde dehydrogenase 1 soluble; aldehyde dehydrogenase 1, liver cytosolic (class 1); aldehyde dehydrogenase 1, soluble; aldehyde dehydrogenase 1, subfamily A1; Aldehyde dehydrogenase 1A1; aldehyde dehydrogenase 2; Aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase family 1, member A1; aldehyde dehydrogenase family 1, subfamily A1; Aldehyde dehydrogenase, cytosolic; aldehyde dehydrogenase, liver cytosolic; ALDH class 1; ALDH-E1; ALHDII; epididymis luminal protein 12; epididymis luminal protein 9; epididymis secretory sperm binding protein Li 53e; epididymis secretory sperm binding protein Li53e; MGC2318; oxidoreductase; RALDH 1; ralDH1; Retinal dehydrogenase 1; retinaldehyde dehydrogenase 1; unnamed protein product
Gene Aliases: Ahd-2; Ahd2; ALDC; Aldh; ALDH-E1; ALDH1; ALDH11; ALDH1A1; Aldh1a2; Aldh2; E1; HEL-9; HEL-S-53e; HEL12; PUMB1; RALDH1
UniProt ID: (Human) P00352, (Mouse) P24549, (Rat) P51647
Entrez Gene ID: (Human) 216, (Mouse) 11668, (Rat) 24188
nucleotide binding
retinal dehydrogenase activity
aldehyde dehydrogenase (NAD) activity
GTPase activator activity
androgen binding
protein binding
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
benzaldehyde dehydrogenase (NAD+) activity
aminobutyraldehyde dehydrogenase activity
NAD binding
3-deoxyglucosone dehydrogenase activity
acetaldehyde dehydrogenase (NAD+) activity
3-chloroallyl aldehyde dehydrogenase activity
identical protein binding
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
retinoid metabolic process
cellular aldehyde metabolic process
lipid metabolic process
gamma-aminobutyric acid biosynthetic process
fructosamine catabolic process
maintenance of lens transparency
retinol metabolic process
cellular detoxification of aldehyde
negative regulation of cold-induced thermogenesis
optic cup morphogenesis involved in camera-type eye development
retinoic acid biosynthetic process
response to oxidative stress
metabolic process
response to drug
retinoic acid metabolic process
9-cis-retinoic acid biosynthetic process
9-cis-retinoic acid metabolic process
positive regulation of apoptotic process
response to ethanol
embryonic eye morphogenesis
protein homotetramerization
oxidation-reduction process
kidney development
liver development
midgut development
response to organic cyclic compound
response to estradiol
response to retinoic acid
estrous cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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