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Invitrogen
ALDH2 Polyclonal Antibody
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ALDH2 Antibody (PA5-27414) in IHC (P)
ALDH2 Polyclonal Antibody detects ALDH2 protein at mitochondria on mouse prostate by immunohistochemical analysis. Sample: Paraffin-embedded mouse prostate. ALDH2 Polyclonal Antibody (Product # PA5-27414) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-27414
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human ALDH2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: GL261, C8D30, BCL-1, Raw264.7, HepG2, HepG2 cytoplasm extract.
Predicted reactivity: Mouse (95%), Rat (96%), Xenopus laevis (82%), Pig (94%), Bovine (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ALDH2 belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Asians have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Asians than among Caucasians could be related to the absence of the mitochondrial isozyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: acetaldehyde dehydrogenase 2; AHD-M1; aldehyde dehydrogenase 2, mitochondrial; Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDH1; ALDHI; EC 1.2.1.3; liver mitochondrial ALDH; MGC1806; mitochondrial aldehyde dehydrogenase; nucleus-encoded mitochondrial aldehyde dehydrogenase 2
Gene Aliases: Ahd-1; Ahd-5; AHD-M1; Ahd1; Ahd5; ALDH-E2; ALDH2; ALDHI; ALDM
UniProt ID: (Human) P05091, (Rat) P11884, (Mouse) P47738
Entrez Gene ID: (Human) 217, (Rat) 29539, (Mouse) 11669
aldehyde dehydrogenase (NAD) activity
aldehyde dehydrogenase [NAD(P)+] activity
electron carrier activity
protein binding
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
identical protein binding
NADH binding
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
carbohydrate metabolic process
alcohol metabolic process
ethanol catabolic process
ethanol oxidation
liver development
response to estradiol
response to lipopolysaccharide
response to progesterone
cellular response to hormone stimulus
response to testosterone
response to nicotine
negative regulation of apoptotic process
response to hyperoxia
oxidation-reduction process
cellular response to fatty acid
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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