Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Rockland
ALDH5A1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 1
ALDH5A1 Antibody (600-401-Y04) in WB
Western Blot of Aldh5A1 antibody. Lane A: Mouse liver lysate at 1 µg/mL. Lane B: Mouse liver lysate at 2 µg/mL. Load: 35 µg per lane. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: 57.2 kDa, ~55 kDa for Aldh5A1.
Product Details
600-401-Y04
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-Aldh5A1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 22 amino acid synthetic peptide near the C-terminus of the human Aldh5A1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Aldh5A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh5A1 is a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, results in a disorder of the neurotransmitter 4-aminobutyric acid (GABA). Symptoms usually include static encephalopathy, associated with developmental delays, hypotonia, ataxia, speech defects, and seizures. At least two isoforms of Aldh5A1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: aldehyde dehydrogenase 1, mitochondrial; aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase); Aldehyde dehydrogenase family 5 member A1; aldehyde dehydrogenase family 5, subfamily A1; mitochondrial succinate semialdehyde dehydrogenase; NAD(+)-dependent succinic semialdehyde dehydrogenase; Succinate-semialdehyde dehydrogenase, mitochondrial; succinic semialdehyde dehydrogenase
Gene Aliases: 6330403E24Rik; Ahd-1; Ahd1; ALDH5A1; D630032B01Rik; OTTMUSG00000000613; SSADH; SSDH; Ssdh1
UniProt ID: (Human) P51649, (Mouse) Q8BWF0
Entrez Gene ID: (Human) 7915, (Mouse) 214579, (Rat) 291133
aldehyde dehydrogenase (NAD) activity
succinate-semialdehyde dehydrogenase (NAD+) activity
succinate-semialdehyde dehydrogenase [NAD(P)+] activity
carboxylic acid binding
protein homodimerization activity
NAD binding
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
glucose metabolic process
acetate metabolic process
succinate metabolic process
glutamate metabolic process
glutamine metabolic process
glycerophospholipid metabolic process
glucosylceramide metabolic process
galactosylceramide metabolic process
glutathione metabolic process
central nervous system development
gamma-aminobutyric acid catabolic process
post-embryonic development
respiratory electron transport chain
neurotransmitter catabolic process
short-chain fatty acid metabolic process
protein homotetramerization
metabolic process
gamma-aminobutyric acid metabolic process
oxidation-reduction process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support