Immunogen sequence: SRALREPYMD EIFHLPQAQR YCEGHFSLSQ WDPMITTLP
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
ALG10 encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel.
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Protein Aliases: Alpha-1,2-glucosyltransferase ALG10-A; Alpha-2-glucosyltransferase ALG10-A; alpha2-glucosyltransferase; asparagine-linked glycosylation 10 homolog (yeast, alpha-1,2-glucosyltransferase); asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog; Asparagine-linked glycosylation protein 10 homolog A; derepression of ITR1 expression 2 homolog; Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase; potassium channel regulator 1
Gene Aliases: ALG10; ALG10A; DIE2; KCR1
UniProt ID: (Human) Q5BKT4
Entrez Gene ID: (Human) 84920