Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase; alkB, alkylation repair homolog 3; Alkylated DNA repair protein alkB homolog 3; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; DEPC 1; DEPC-1; FLJ43614; hABH3; m MGC118790; mAbh3; MGC118792; MGC118793; MGC134125; Prostate cancer antigen 1; prostate cancer antigen-1; RP23-375N21.4
Gene Aliases: 1700108H04Rik; 1810020C19Rik; ABH3; ALKBH3; DEPC-1; DEPC1; hABH3; mABH3; PCA1