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Product Details
MA5-30056
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
027
Immunogen
Recombinant Human ALOX15B/15 Lipoxygenase 2 Protein (Met1-Ile676)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2785844
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human ALOX15B/15 Lipoxygenase 2.
Target Information
ALOX15B encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 15-lipoxygenase 2; 15-LOX-2; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenase 2; Arachidonate 15-lipoxygenase B; Arachidonate 15-lipoxygenase type II; arachidonate 15-lipoxygenase, second type; arachidonate omega(6) lipoxygenase; Linoleate 13-lipoxygenase 15-LOb; Polyunsaturated fatty acid lipoxygenase ALOX15B
Gene Aliases: 15-LOX-2; ALOX15B
UniProt ID: (Human) D3DTR2
Entrez Gene ID: (Human) 247
lipid metabolic process
apoptotic process
negative regulation of cell proliferation
positive regulation of macrophage derived foam cell differentiation
arachidonic acid metabolic process
lipoxygenase pathway
negative regulation of cell migration
prostate gland development
regulation of epithelial cell differentiation
positive regulation of peroxisome proliferator activated receptor signaling pathway
linoleic acid metabolic process
positive regulation of keratinocyte differentiation
negative regulation of cell cycle
negative regulation of growth
hepoxilin biosynthetic process
oxidation-reduction process
positive regulation of chemokine secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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