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Invitrogen
ALOX5 Polyclonal Antibody
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Product Details
PA5-95034
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human ALOX5 (650-667aa AERNKKKQLPYYYLSPDR).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: SW620 whole cell, JURKAT whole cell, COLO320 whole cell, A549 whole cell, MCF-7 whole cell. IHC: Human Lung Cancer Tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
This gene encodes a protein which, with Arachidonate 5-lipoxygenase-activating protein, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 5-LO; Arachidonate 5-lipoxygenase; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; lipoxygenase; LOX-5; lox5; Polyunsaturated fatty acid 5-lipoxygenase; RP11-67C2.3
Gene Aliases: 5-LO; 5-LOX; 5LPG; ALOX5; LOG5
UniProt ID: (Human) P09917
Entrez Gene ID: (Human) 240
arachidonate 5-lipoxygenase activity
arachidonate 12-lipoxygenase activity
iron ion binding
protein binding
oxidoreductase activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
hydrolase activity
arachidonate 8(S)-lipoxygenase activity
metal ion binding
dioxygenase activity
long-chain fatty acid metabolic process
negative regulation of endothelial cell proliferation
leukocyte chemotaxis involved in inflammatory response
leukocyte migration involved in inflammatory response
leukotriene production involved in inflammatory response
lipid metabolic process
icosanoid metabolic process
leukotriene metabolic process
response to stress
inflammatory response
humoral immune response
negative regulation of angiogenesis
arachidonic acid metabolic process
leukotriene biosynthetic process
lipoxygenase pathway
positive regulation of bone mineralization
lipid oxidation
dendritic cell migration
glucose homeostasis
long-chain fatty acid biosynthetic process
regulation of fat cell differentiation
regulation of inflammatory response
negative regulation of inflammatory response
regulation of insulin secretion
negative regulation of vascular wound healing
negative regulation of wound healing
regulation of inflammatory response to wounding
regulation of cytokine production involved in inflammatory response
regulation of cellular response to oxidative stress
leukotriene A4 biosynthetic process
regulation of reactive oxygen species biosynthetic process
negative regulation of response to endoplasmic reticulum stress
negative regulation of sprouting angiogenesis
positive regulation of leukocyte adhesion to arterial endothelial cell
lipoxin biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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