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Proteintech
AMOT Polyclonal Antibody
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Product Details
16870-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.34 mg/mL
Amount
51 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes p130 only.
Target Information
AMOT (Angiomotin) belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. AMOT plays a central role in tight junction maintenance via the complex formed with ARHGAP17 - which acts by regulating the uptake of polarity proteins at tight junctions. AMOT is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Angiomotin; unnamed protein product
Gene Aliases: AMOT; CAG-2; D0Kist1; KIAA1071; RGD1564027; Sii6
UniProt ID: (Human) Q4VCS5, (Mouse) Q8VHG2
Entrez Gene ID: (Human) 154796, (Mouse) 27494, (Rat) 300289
vasculogenesis
in utero embryonic development
gastrulation with mouth forming second
establishment of cell polarity involved in ameboidal cell migration
chemotaxis
negative regulation of angiogenesis
actin cytoskeleton organization
regulation of cell migration
negative regulation of GTPase activity
cellular protein localization
hippo signaling
positive regulation of embryonic development
cell migration involved in gastrulation
negative regulation of vascular permeability
blood vessel endothelial cell migration
positive regulation of blood vessel endothelial cell migration
blood vessel morphogenesis
regulation of small GTPase mediated signal transduction
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
cell-cell junction assembly
protein localization
positive regulation of cell size
positive regulation of stress fiber assembly
regulation of modification of postsynaptic actin cytoskeleton
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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