PA1-21909 detects AMPK alpha 1 in bovine, human and rat samples.
PA1-21909 has been successfully used in Immunoprecipitation and Western Blot procedures. Predicted molecular weight: 63 kDa.
The PA1-21909 immunogen is a synthetic peptide corresponding to the alpha1 catalytic subunit within exon 8 of human AMP activated protein Kinase (AMPK).
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 5'-AMP-activated protein kinase catalytic subunit alpha-1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; ACACA kinase; Acetyl-CoA carboxylase kinase; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase, catalytic, alpha-1; AMPK; AMPK alpha 1; AMPK alpha-1 chain; AMPK subunit alpha-1; AMPKa1; HMGCR kinase; Hydroxymethylglutaryl-CoA reductase kinase; MGC33776; MGC57364; protein kinase, AMP-activated, alpha 1 catalytic subunit; Tau-protein kinase PRKAA1
Gene Aliases: AMPK; AMPK1; AMPKa1; AMPKalpha1; BOS_19826; PRKAA1