AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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Protein Aliases: 5'-AMP-activated protein kinase subunit gamma-2; 5-AMP-activated protein kinase, gamma-2 subunit; AAKG; AAKG2; AMPK gamma-2 chain; AMPK gamma2; AMPK subunit gamma 2; AMPK subunit gamma-2; CMH6; H91620p; PRKAG2; protein kinase, AMP-activated, gamma 2 non-catalytic subunit; WPWS
Gene Aliases: 2410051C13Rik; AAKG; AAKG2; AI854673; CMH6; H91620p; PRKAG2; WPWS