Immunogen sequence: MASVHESLY FNPMMTNGVV HANVFGIKDW VTPYKIAVLV LLNEMSRTGE GAVSLMERRR LNQLLLPLLQ GPDITLSKLY KLIEESCPQL ANSVQIRIKL MAEGELKDME QFFDDLSDSF SGTEPEVHKT SVVGLFLRHM ILAYSKLSFS QVFKLYTALQ QYFQNGEKKT VEDADMELTS RDEGERKMEK EELDVSVREE EVSCSGPLSQ KQAEFFLSQQ ASLLKNDETK ALTPASLQKE LNNLLKFNPD FAEAHYLSYL NNLRVQDVFS STHSLLHYFD RLILTGAESK SNGEEGYGRS LRYAALNLAA LHCRFGHYQQ AELALQEAIR IAQESNDHVC LQHC (1-343 aa encoded by BC001081)
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome, a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein, compared to isoform a.
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Protein Aliases: Anaphase-promoting complex subunit 5; APC5; Cyclosome subunit 5
Gene Aliases: 2510006G12Rik; AA408751; AA536819; AA986414; ANAPC5; Anpc5; APC5; MNCb-2778