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Product Details
14926-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ANAPC5 Fusion Protein Ag6688 (1-343 aa encoded by BC001081)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
Immunogen sequence: MASVHESLY FNPMMTNGVV HANVFGIKDW VTPYKIAVLV LLNEMSRTGE GAVSLMERRR LNQLLLPLLQ GPDITLSKLY KLIEESCPQL ANSVQIRIKL MAEGELKDME QFFDDLSDSF SGTEPEVHKT SVVGLFLRHM ILAYSKLSFS QVFKLYTALQ QYFQNGEKKT VEDADMELTS RDEGERKMEK EELDVSVREE EVSCSGPLSQ KQAEFFLSQQ ASLLKNDETK ALTPASLQKE LNNLLKFNPD FAEAHYLSYL NNLRVQDVFS STHSLLHYFD RLILTGAESK SNGEEGYGRS LRYAALNLAA LHCRFGHYQQ AELALQEAIR IAQESNDHVC LQHC (1-343 aa encoded by BC001081)
Target Information
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome, a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein, compared to isoform a.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Anaphase-promoting complex subunit 5; APC5; Cyclosome subunit 5
Gene Aliases: 2510006G12Rik; AA408751; AA536819; AA986414; ANAPC5; Anpc5; APC5; MNCb-2778
UniProt ID: (Human) Q9UJX4, (Rat) A1L1K3, (Mouse) Q8BTZ4
Entrez Gene ID: (Human) 51433, (Rat) 288671, (Mouse) 59008
mitotic nuclear division
cell division
protein K11-linked ubiquitination
anaphase-promoting complex-dependent catabolic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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